The first wave of B lymphopoiesis develops independently of stem cells in the murine embryo

Momoko Yoshimoto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In the developing mouse embryo, there are several waves of hematopoiesis. Primitive and definitive erythromyeloid lineages appear prior to hematopoietic stem cell (HSC) emergence, and these waves are considered to be transient and support embryonic homeostasis until HSC-derived hematopoiesis is established. However, recent evidence strongly suggests that HSC-independent immune cells, such as tissue macrophages and some innate lymphoid cells, develop in the mouse embryo and persist into postnatal life. Innate type B-1 cells have also been reported to emerge from hemogenic endothelial cells in the extraembryonic yolk sac and para-aortic splanchnopleura, and continue to develop in the fetal liver, even in HSC-deficient mouse embryos. Here, this review discusses B-1 cell development in the context of the layered immune system hypothesis of B lymphopoiesis and the emergence of B-1 cells independent of HSCs.

Original languageEnglish (US)
Pages (from-to)16-22
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1362
Issue number1
DOIs
StatePublished - Dec 1 2015

Fingerprint

Lymphopoiesis
Hematopoietic Stem Cells
Stem cells
Stem Cells
Embryonic Structures
Hematopoiesis
Hemangioblasts
Yolk Sac
Macrophages
Immune system
Endothelial cells
Liver
Immune System
Homeostasis
Lymphocytes
Tissue
Embryo
Waves
Cells
Mouse

Keywords

  • B-1
  • Core-binding factor β, hemogenic endothelial cells
  • Hematopoietic stem cells
  • Marginal zone B cells
  • Para-aortic splanchnopleura
  • Yolk sac

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

The first wave of B lymphopoiesis develops independently of stem cells in the murine embryo. / Yoshimoto, Momoko.

In: Annals of the New York Academy of Sciences, Vol. 1362, No. 1, 01.12.2015, p. 16-22.

Research output: Contribution to journalArticle

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