The folate receptor as a molecular target for tumor-selective radionuclide delivery

Chun Yen Ke, Carla J. Mathias, Mark A. Green

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

The cell-membrane folate receptor is a potential molecular target for tumor-selective drug delivery, including radiolabeled folate-chelate conjugates for diagnostic imaging. We review here some background on the folate receptor as tumor-associated molecular target for drug delivery, and briefly survey the literature on tumor-targeting with radiolabeled folate-chelate conjugates.

Original languageEnglish (US)
Pages (from-to)811-817
Number of pages7
JournalNuclear Medicine and Biology
Volume30
Issue number8
DOIs
StatePublished - Nov 2003
Externally publishedYes

Keywords

  • Folate binding protein
  • Folate receptor
  • Radionuclide imaging
  • Radiopharmaceutical
  • Tumor targeting

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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