The folate receptor as a molecular target for tumor-selective radionuclide delivery

Chun Yen Ke, Carla J. Mathias, Mark Green

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The cell-membrane folate receptor is a potential molecular target for tumor-selective drug delivery, including radiolabeled folate-chelate conjugates for diagnostic imaging. We review here some background on the folate receptor as tumor-associated molecular target for drug delivery, and briefly survey the literature on tumor-targeting with radiolabeled folate-chelate conjugates.

Original languageEnglish (US)
Pages (from-to)811-817
Number of pages7
JournalNuclear Medicine and Biology
Volume30
Issue number8
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Folic Acid
Radioisotopes
Neoplasms
Diagnostic Imaging
Pharmaceutical Preparations
Cell Membrane

Keywords

  • Folate binding protein
  • Folate receptor
  • Radionuclide imaging
  • Radiopharmaceutical
  • Tumor targeting

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

The folate receptor as a molecular target for tumor-selective radionuclide delivery. / Ke, Chun Yen; Mathias, Carla J.; Green, Mark.

In: Nuclear Medicine and Biology, Vol. 30, No. 8, 11.2003, p. 811-817.

Research output: Contribution to journalArticle

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