The glomerular filtration barrier in the spontaneously hypertensive rat

Andrew Evan, Friedrich C. Luft, Vincent Gattone, Brett A. Connors, David A. McCarron, Lynn R. Willis

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To determine whether the differences in the physiological characteristics of SHR and WKY kidneys might be related to differences in renal structure, we studied the kidneys of SHR and WKY rats utilizing scanning and transmission electron microscopy and latex perfusion of the glomerular vasculature. Scanning and transmission electron microscopy revealed a smaller diameter in the glomerular endothelial fenestrae of SHR compared to that in WKY rats even prior to the development of differences in blood pressure. With age, the density and diameter of SHR endothelial fenestrae progressively decreased, which was not true in WKY rats. Latex casts of glomerular vasculature showed the frequent presence of afferent arteriolar constriction in 12-week-old SHR. Thus, the filtration barrier of the SHR is abnormal. The pathogenesis of hypertension in the SHR is complex and probably multifactorial; however, renal structural changes may contribute to the development and maintenance of hypertension. The afferent arteriolar constrictions may be the structural basis for the increased vascular resistance described in the SHR.

Original languageEnglish
Pages (from-to)154-161
Number of pages8
JournalHypertension
Volume3
Issue number3
StatePublished - 1981

Fingerprint

Glomerular Filtration Barrier
Inbred SHR Rats
Inbred WKY Rats
Kidney
Scanning Transmission Electron Microscopy
Latex
Constriction
Hypertension
Vascular Resistance
Perfusion
Maintenance
Blood Pressure

Keywords

  • Endothelial fenestrae
  • Glomerular filtration barrier
  • Kidney structure
  • Renal
  • Vascular resistance

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Evan, A., Luft, F. C., Gattone, V., Connors, B. A., McCarron, D. A., & Willis, L. R. (1981). The glomerular filtration barrier in the spontaneously hypertensive rat. Hypertension, 3(3), 154-161.

The glomerular filtration barrier in the spontaneously hypertensive rat. / Evan, Andrew; Luft, Friedrich C.; Gattone, Vincent; Connors, Brett A.; McCarron, David A.; Willis, Lynn R.

In: Hypertension, Vol. 3, No. 3, 1981, p. 154-161.

Research output: Contribution to journalArticle

Evan, A, Luft, FC, Gattone, V, Connors, BA, McCarron, DA & Willis, LR 1981, 'The glomerular filtration barrier in the spontaneously hypertensive rat', Hypertension, vol. 3, no. 3, pp. 154-161.
Evan A, Luft FC, Gattone V, Connors BA, McCarron DA, Willis LR. The glomerular filtration barrier in the spontaneously hypertensive rat. Hypertension. 1981;3(3):154-161.
Evan, Andrew ; Luft, Friedrich C. ; Gattone, Vincent ; Connors, Brett A. ; McCarron, David A. ; Willis, Lynn R. / The glomerular filtration barrier in the spontaneously hypertensive rat. In: Hypertension. 1981 ; Vol. 3, No. 3. pp. 154-161.
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