The good and evil of complement activation in HIV-1 infection

Qigui Yu, Richard Yu, Xuebin Qin

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

The complement system, a key component of innate immunity, is a first-line defender against foreign pathogens such as HIV-1. The role of the complement system in HIV-1 pathogenesis appears to be multifaceted. Although the complement system plays critical roles in clearing and neutralizing HIV-1 virions, it also represents a critical factor for the spread and maintenance of the virus in the infected host. In addition, complement regulators such as human CD59 present in the envelope of HIV-1 prevent complement-mediated lysis of HIV-1. Some novel approaches are proposed to combat HIV-1 infection through the enhancement of antibody-dependent complement activity against HIV-1. In this paper, we will review these diverse roles of complement in HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)334-340
Number of pages7
JournalCellular and Molecular Immunology
Volume7
Issue number5
DOIs
StatePublished - Dec 1 2010

Keywords

  • antibody
  • complement
  • HIV-1
  • human CD59

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology
  • Medicine(all)

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