The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Andrea Shin, Geoffrey A. Preidis, Robert Shulman, Purna C. Kashyap

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota–host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain–gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.

Original languageEnglish (US)
Pages (from-to)256-274
Number of pages19
JournalClinical Gastroenterology and Hepatology
Volume17
Issue number2
DOIs
StatePublished - Jan 1 2019

Fingerprint

Gastrointestinal Diseases
Microbiota
Pediatrics
Physiological Phenomena
Aptitude
Gastrointestinal Motility
Ecosystem
Animal Models
Communication
Gastrointestinal Microbiome
Therapeutics
Research
Direction compound

Keywords

  • Abdominal Pain
  • Brain-Gut
  • Constipation
  • Dyspepsia
  • Irritable Bowel Syndrome
  • Microbiota

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders. / Shin, Andrea; Preidis, Geoffrey A.; Shulman, Robert; Kashyap, Purna C.

In: Clinical Gastroenterology and Hepatology, Vol. 17, No. 2, 01.01.2019, p. 256-274.

Research output: Contribution to journalReview article

Shin, Andrea ; Preidis, Geoffrey A. ; Shulman, Robert ; Kashyap, Purna C. / The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders. In: Clinical Gastroenterology and Hepatology. 2019 ; Vol. 17, No. 2. pp. 256-274.
@article{b63a17e09d76423a81dc21eaa36bf544,
title = "The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders",
abstract = "The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota–host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain–gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.",
keywords = "Abdominal Pain, Brain-Gut, Constipation, Dyspepsia, Irritable Bowel Syndrome, Microbiota",
author = "Andrea Shin and Preidis, {Geoffrey A.} and Robert Shulman and Kashyap, {Purna C.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.cgh.2018.08.054",
language = "English (US)",
volume = "17",
pages = "256--274",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

AU - Shin, Andrea

AU - Preidis, Geoffrey A.

AU - Shulman, Robert

AU - Kashyap, Purna C.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota–host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain–gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.

AB - The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota–host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain–gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.

KW - Abdominal Pain

KW - Brain-Gut

KW - Constipation

KW - Dyspepsia

KW - Irritable Bowel Syndrome

KW - Microbiota

UR - http://www.scopus.com/inward/record.url?scp=85059185857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059185857&partnerID=8YFLogxK

U2 - 10.1016/j.cgh.2018.08.054

DO - 10.1016/j.cgh.2018.08.054

M3 - Review article

VL - 17

SP - 256

EP - 274

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 2

ER -