The hedgehog's trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors

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3 Citations (Scopus)

Abstract

Myeloid-derived suppressor cells (MDSCs) are an important means by which tumor cells evade immunosurveillance. Here, we set out to determine how MDSCs are recruited to tumors in genetically engineered mouse cancer models. Expression of oncogenic and constitutively active SmoM2, a key hedgehog-signaling regulatory protein, revealed that MDSC recruitment to the tumor microenvironment is mediated by the CCL2/CCR2 axis in a TGFβ dependent fashion.

Original languageEnglish
Article numbere29180
JournalOncoImmunology
Volume3
Issue number6
DOIs
StatePublished - 2014

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Immunologic Monitoring
Hedgehogs
Neoplasms
Tumor Microenvironment
Myeloid-Derived Suppressor Cells
Proteins

Keywords

  • Basal cell carcinoma
  • Cancer
  • CCL2
  • Hedgehog
  • Immune suppression
  • MDSC
  • Mouse models
  • Rhabdomyosarcoma
  • Smoothened
  • Tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

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abstract = "Myeloid-derived suppressor cells (MDSCs) are an important means by which tumor cells evade immunosurveillance. Here, we set out to determine how MDSCs are recruited to tumors in genetically engineered mouse cancer models. Expression of oncogenic and constitutively active SmoM2, a key hedgehog-signaling regulatory protein, revealed that MDSC recruitment to the tumor microenvironment is mediated by the CCL2/CCR2 axis in a TGFβ dependent fashion.",
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AB - Myeloid-derived suppressor cells (MDSCs) are an important means by which tumor cells evade immunosurveillance. Here, we set out to determine how MDSCs are recruited to tumors in genetically engineered mouse cancer models. Expression of oncogenic and constitutively active SmoM2, a key hedgehog-signaling regulatory protein, revealed that MDSC recruitment to the tumor microenvironment is mediated by the CCL2/CCR2 axis in a TGFβ dependent fashion.

KW - Basal cell carcinoma

KW - Cancer

KW - CCL2

KW - Hedgehog

KW - Immune suppression

KW - MDSC

KW - Mouse models

KW - Rhabdomyosarcoma

KW - Smoothened

KW - Tumor microenvironment

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