The history of myasthenia gravis.

Research output: Contribution to journalArticle

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Abstract

The first case of myasthenia gravis (MG) was described in 1672. Treatment of MG was negligible until Mary Walker's seminal observation in 1934 of improvement with physostigmine and neostigmine injections. Blalock reported the initial success with thymectomy around 1940. Edrophonium was introduced around 1950 and pyridostigmine in the mid-1950s. John Simpson's hypothesis of an autoimmune etiology for MG in 1960 was later proven correct, and subsequent use of immunosuppressive therapy including corticosteroids led to the modern era in management of MG.

Original languageEnglish
Pages (from-to)231-242
Number of pages12
JournalNeurologic Clinics
Volume12
Issue number2
StatePublished - May 1994

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Myasthenia Gravis
History
Edrophonium
Pyridostigmine Bromide
Neostigmine
Thymectomy
Physostigmine
Immunosuppressive Agents
Adrenal Cortex Hormones
Observation
Injections
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

The history of myasthenia gravis. / Pascuzzi, Robert.

In: Neurologic Clinics, Vol. 12, No. 2, 05.1994, p. 231-242.

Research output: Contribution to journalArticle

Pascuzzi, Robert. / The history of myasthenia gravis. In: Neurologic Clinics. 1994 ; Vol. 12, No. 2. pp. 231-242.
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