The human calvaria: A review of embryology, anatomy, pathology, and molecular development

R. Shane Tubbs, Anand N. Bosmia, Aaron A. Cohen-Gadol

Research output: Contribution to journalReview article

35 Scopus citations


Introduction: The human skull is a complex structure that deserves continued study. Few studies have directed their attention to the development, pathology, and molecular formation of the human calvaria. Materials and methods: A review of the medical literature using standard search engines was performed to locate studies regarding the human calvaria. Results: The formation of the human calvaria is a complex interaction between bony and meningeal elements. Derailment of these interactions may result in deformation of this part of the skull. Conclusions: Knowledge of the anatomy, formation, and pathology of the human calvaria will be of use to the clinician that treats skull diseases. With an increased understanding of genetic and molecular biology, treatment paradigms for calvarial issues may change.

Original languageEnglish (US)
Pages (from-to)23-31
Number of pages9
JournalChild's Nervous System
Issue number1
StatePublished - Jan 1 2012


  • Calvaria
  • Craniosynostosis
  • Dura
  • Neurocranium
  • Suture

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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