The human glycine receptor: A new probe that is linked to the X-linked hypophosphatemic rickets gene

Michael Econs, M. A. Pericak-Vance, H. Betz, R. J. Bartlett, M. C. Speer, M. K. Drezner

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We undertook linkage analysis in four large North Carolina kindreds with X-linked hypophosphatemic rickets (HYP) using a newly defined polymorphic probe, derived from the 5′ untranslated portion of the human glycine receptor (GLR). Two-point linkage analysis established linkage between GLR and HYP [Z(θ) = 7.91 at θ = 0.07] and confirmed linkage between HYP and DXS41 [Z(θ) = 8.31 at θ = 0.06] and DXS43 [Z(θ) = 5.94 at θ = 0.05]. Additionally, we found GLR tightly linked to DXS43 [Z(θ) = 5.40 at θ = 0.0]. Multipoint analysis indicated that GLR is on the telomeric side of HYP with a map order of Xpcen-DXS41-HYP-( GLR DXS43).

Original languageEnglish (US)
Pages (from-to)439-441
Number of pages3
JournalGenomics
Volume7
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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Familial Hypophosphatemic Rickets
Glycine Receptors
Hypophosphatemic Rickets
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Econs, M., Pericak-Vance, M. A., Betz, H., Bartlett, R. J., Speer, M. C., & Drezner, M. K. (1990). The human glycine receptor: A new probe that is linked to the X-linked hypophosphatemic rickets gene. Genomics, 7(3), 439-441. https://doi.org/10.1016/0888-7543(90)90180-3

The human glycine receptor : A new probe that is linked to the X-linked hypophosphatemic rickets gene. / Econs, Michael; Pericak-Vance, M. A.; Betz, H.; Bartlett, R. J.; Speer, M. C.; Drezner, M. K.

In: Genomics, Vol. 7, No. 3, 1990, p. 439-441.

Research output: Contribution to journalArticle

Econs, M, Pericak-Vance, MA, Betz, H, Bartlett, RJ, Speer, MC & Drezner, MK 1990, 'The human glycine receptor: A new probe that is linked to the X-linked hypophosphatemic rickets gene', Genomics, vol. 7, no. 3, pp. 439-441. https://doi.org/10.1016/0888-7543(90)90180-3
Econs, Michael ; Pericak-Vance, M. A. ; Betz, H. ; Bartlett, R. J. ; Speer, M. C. ; Drezner, M. K. / The human glycine receptor : A new probe that is linked to the X-linked hypophosphatemic rickets gene. In: Genomics. 1990 ; Vol. 7, No. 3. pp. 439-441.
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abstract = "We undertook linkage analysis in four large North Carolina kindreds with X-linked hypophosphatemic rickets (HYP) using a newly defined polymorphic probe, derived from the 5′ untranslated portion of the human glycine receptor (GLR). Two-point linkage analysis established linkage between GLR and HYP [Z(θ) = 7.91 at θ = 0.07] and confirmed linkage between HYP and DXS41 [Z(θ) = 8.31 at θ = 0.06] and DXS43 [Z(θ) = 5.94 at θ = 0.05]. Additionally, we found GLR tightly linked to DXS43 [Z(θ) = 5.40 at θ = 0.0]. Multipoint analysis indicated that GLR is on the telomeric side of HYP with a map order of Xpcen-DXS41-HYP-( GLR DXS43).",
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