The human microbiota and prostate cancer: Friend or foe?

Francesco Massari, Veronica Mollica, Vincenzo Di Nunno, Lidia Gatto, Matteo Santoni, Marina Scarpelli, Alessia Cimadamore, Antonio Lopez-Beltran, Liang Cheng, Nicola Battelli, Rodolfo Montironi, Giovanni Brandi

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

The human microbiome is gaining increasing attention in the medical community, as knowledge on its role not only in health but also in disease development and response to therapies is expanding. Furthermore, the connection between the microbiota and cancer, especially the link between the gut microbiota and gastrointestinal tumors, is becoming clearer. The interaction between the microbiota and the response to chemotherapies and, more recently, to immunotherapy has been widely studied, and a connection between a peculiar type of microbiota and a better response to these therapies and a different incidence in toxicities has been hypothesized. As knowledge on the gut microbiota increases, interest in the residing microbial population in other systems of our body is also increasing. Consequently, the urinary microbiota is under evaluation for its possible implications in genitourinary diseases, including cancer. Prostate cancer is the most common cancer in the male population; thus, research regarding its etiology and possible factors correlated to disease progression or the response to specific therapies is thriving. This review has the purpose to recollect the current knowledge on the relationship between the human microbiota and prostate cancer.

Original languageEnglish (US)
Article number459
JournalCancers
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Microbiota
Prostatic Neoplasms
Neoplasms
Immunotherapy
Population
Disease Progression
Therapeutics
Drug Therapy
Incidence
Health
Research

Keywords

  • Genitourinary cancers
  • Microbiome
  • Microbiota
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Massari, F., Mollica, V., Di Nunno, V., Gatto, L., Santoni, M., Scarpelli, M., ... Brandi, G. (2019). The human microbiota and prostate cancer: Friend or foe? Cancers, 11(4), [459]. https://doi.org/10.3390/cancers11040459

The human microbiota and prostate cancer : Friend or foe? / Massari, Francesco; Mollica, Veronica; Di Nunno, Vincenzo; Gatto, Lidia; Santoni, Matteo; Scarpelli, Marina; Cimadamore, Alessia; Lopez-Beltran, Antonio; Cheng, Liang; Battelli, Nicola; Montironi, Rodolfo; Brandi, Giovanni.

In: Cancers, Vol. 11, No. 4, 459, 01.04.2019.

Research output: Contribution to journalReview article

Massari, F, Mollica, V, Di Nunno, V, Gatto, L, Santoni, M, Scarpelli, M, Cimadamore, A, Lopez-Beltran, A, Cheng, L, Battelli, N, Montironi, R & Brandi, G 2019, 'The human microbiota and prostate cancer: Friend or foe?', Cancers, vol. 11, no. 4, 459. https://doi.org/10.3390/cancers11040459
Massari F, Mollica V, Di Nunno V, Gatto L, Santoni M, Scarpelli M et al. The human microbiota and prostate cancer: Friend or foe? Cancers. 2019 Apr 1;11(4). 459. https://doi.org/10.3390/cancers11040459
Massari, Francesco ; Mollica, Veronica ; Di Nunno, Vincenzo ; Gatto, Lidia ; Santoni, Matteo ; Scarpelli, Marina ; Cimadamore, Alessia ; Lopez-Beltran, Antonio ; Cheng, Liang ; Battelli, Nicola ; Montironi, Rodolfo ; Brandi, Giovanni. / The human microbiota and prostate cancer : Friend or foe?. In: Cancers. 2019 ; Vol. 11, No. 4.
@article{dd3fea655edf41b0a1587f579b87c820,
title = "The human microbiota and prostate cancer: Friend or foe?",
abstract = "The human microbiome is gaining increasing attention in the medical community, as knowledge on its role not only in health but also in disease development and response to therapies is expanding. Furthermore, the connection between the microbiota and cancer, especially the link between the gut microbiota and gastrointestinal tumors, is becoming clearer. The interaction between the microbiota and the response to chemotherapies and, more recently, to immunotherapy has been widely studied, and a connection between a peculiar type of microbiota and a better response to these therapies and a different incidence in toxicities has been hypothesized. As knowledge on the gut microbiota increases, interest in the residing microbial population in other systems of our body is also increasing. Consequently, the urinary microbiota is under evaluation for its possible implications in genitourinary diseases, including cancer. Prostate cancer is the most common cancer in the male population; thus, research regarding its etiology and possible factors correlated to disease progression or the response to specific therapies is thriving. This review has the purpose to recollect the current knowledge on the relationship between the human microbiota and prostate cancer.",
keywords = "Genitourinary cancers, Microbiome, Microbiota, Prostate cancer",
author = "Francesco Massari and Veronica Mollica and {Di Nunno}, Vincenzo and Lidia Gatto and Matteo Santoni and Marina Scarpelli and Alessia Cimadamore and Antonio Lopez-Beltran and Liang Cheng and Nicola Battelli and Rodolfo Montironi and Giovanni Brandi",
year = "2019",
month = "4",
day = "1",
doi = "10.3390/cancers11040459",
language = "English (US)",
volume = "11",
journal = "Cancers",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

TY - JOUR

T1 - The human microbiota and prostate cancer

T2 - Friend or foe?

AU - Massari, Francesco

AU - Mollica, Veronica

AU - Di Nunno, Vincenzo

AU - Gatto, Lidia

AU - Santoni, Matteo

AU - Scarpelli, Marina

AU - Cimadamore, Alessia

AU - Lopez-Beltran, Antonio

AU - Cheng, Liang

AU - Battelli, Nicola

AU - Montironi, Rodolfo

AU - Brandi, Giovanni

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The human microbiome is gaining increasing attention in the medical community, as knowledge on its role not only in health but also in disease development and response to therapies is expanding. Furthermore, the connection between the microbiota and cancer, especially the link between the gut microbiota and gastrointestinal tumors, is becoming clearer. The interaction between the microbiota and the response to chemotherapies and, more recently, to immunotherapy has been widely studied, and a connection between a peculiar type of microbiota and a better response to these therapies and a different incidence in toxicities has been hypothesized. As knowledge on the gut microbiota increases, interest in the residing microbial population in other systems of our body is also increasing. Consequently, the urinary microbiota is under evaluation for its possible implications in genitourinary diseases, including cancer. Prostate cancer is the most common cancer in the male population; thus, research regarding its etiology and possible factors correlated to disease progression or the response to specific therapies is thriving. This review has the purpose to recollect the current knowledge on the relationship between the human microbiota and prostate cancer.

AB - The human microbiome is gaining increasing attention in the medical community, as knowledge on its role not only in health but also in disease development and response to therapies is expanding. Furthermore, the connection between the microbiota and cancer, especially the link between the gut microbiota and gastrointestinal tumors, is becoming clearer. The interaction between the microbiota and the response to chemotherapies and, more recently, to immunotherapy has been widely studied, and a connection between a peculiar type of microbiota and a better response to these therapies and a different incidence in toxicities has been hypothesized. As knowledge on the gut microbiota increases, interest in the residing microbial population in other systems of our body is also increasing. Consequently, the urinary microbiota is under evaluation for its possible implications in genitourinary diseases, including cancer. Prostate cancer is the most common cancer in the male population; thus, research regarding its etiology and possible factors correlated to disease progression or the response to specific therapies is thriving. This review has the purpose to recollect the current knowledge on the relationship between the human microbiota and prostate cancer.

KW - Genitourinary cancers

KW - Microbiome

KW - Microbiota

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=85064838485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064838485&partnerID=8YFLogxK

U2 - 10.3390/cancers11040459

DO - 10.3390/cancers11040459

M3 - Review article

AN - SCOPUS:85064838485

VL - 11

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 4

M1 - 459

ER -