The identification of a tandem H-DNA structure in the c-MYC nuclease sensitive promoter element

Anthony B. Firulli, Douglas C. Maibenco, Alan J. Kinniburgh

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Previous studies have shown that the c-myc nuclease sensitive element (NSE) is capable of forming H-DNA in vitro. The NSE sequence exhibits strong purine/ pyrimidine strand asymmetry. To study the NSE further, we have isolated the element from other c-myc sequences and have shown that the NSE alone is sufficient for the formation of H-DNA in supercoiled plasmids. We also show that the NSE forms a complex structure containing both H-y3 and H-y5 H-DNA. We term this structure tandem H-DNA.

Original languageEnglish (US)
Pages (from-to)264-270
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume185
Issue number1
DOIs
StatePublished - May 29 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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