The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease

Brent R. Weil, Mariuxi C. Manukyan, Jeremy L. Herrmann, Aaron M. Abarbanell, Jeffrey A. Poynter, Yue Wang, Daniel R. Meldrum

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.

Original languageEnglish (US)
Pages (from-to)78-86
Number of pages9
JournalJournal of Surgical Research
Volume167
Issue number1
DOIs
StatePublished - May 1 2011

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Keywords

  • cancer
  • Crohn's disease
  • immunomodulation
  • immunoprivilege
  • inflammation
  • sepsis
  • SIRS
  • transplant
  • tumor

ASJC Scopus subject areas

  • Surgery

Cite this

Weil, B. R., Manukyan, M. C., Herrmann, J. L., Abarbanell, A. M., Poynter, J. A., Wang, Y., & Meldrum, D. R. (2011). The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease. Journal of Surgical Research, 167(1), 78-86. https://doi.org/10.1016/j.jss.2010.07.019