The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease

Brent R. Weil, Mariuxi C. Manukyan, Jeremy L. Herrmann, Aaron M. Abarbanell, Jeffrey A. Poynter, Yue Wang, Daniel R. Meldrum

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute to the therapeutic effects exerted by these cells. The ability of MSCs to interact with and modulate the functions of a wide variety of immune cells has been recognized as one such mechanism. The implications that the immunomodulatory properties of MSCs may have for the treatment of solid organ rejection, the Systemic Inflammatory Response Syndrome, cancer, and Crohn's disease are reviewed herein.

Original languageEnglish
Pages (from-to)78-86
Number of pages9
JournalJournal of Surgical Research
Volume167
Issue number1
DOIs
StatePublished - May 1 2011

Fingerprint

Mesenchymal Stromal Cells
Systemic Inflammatory Response Syndrome
Therapeutic Uses
Crohn Disease
Pathology
Neoplasms

Keywords

  • cancer
  • Crohn's disease
  • immunomodulation
  • immunoprivilege
  • inflammation
  • sepsis
  • SIRS
  • transplant
  • tumor

ASJC Scopus subject areas

  • Surgery

Cite this

Weil, B. R., Manukyan, M. C., Herrmann, J. L., Abarbanell, A. M., Poynter, J. A., Wang, Y., & Meldrum, D. R. (2011). The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease. Journal of Surgical Research, 167(1), 78-86. https://doi.org/10.1016/j.jss.2010.07.019

The immunomodulatory properties of mesenchymal stem cells : Implications for surgical disease. / Weil, Brent R.; Manukyan, Mariuxi C.; Herrmann, Jeremy L.; Abarbanell, Aaron M.; Poynter, Jeffrey A.; Wang, Yue; Meldrum, Daniel R.

In: Journal of Surgical Research, Vol. 167, No. 1, 01.05.2011, p. 78-86.

Research output: Contribution to journalArticle

Weil, BR, Manukyan, MC, Herrmann, JL, Abarbanell, AM, Poynter, JA, Wang, Y & Meldrum, DR 2011, 'The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease', Journal of Surgical Research, vol. 167, no. 1, pp. 78-86. https://doi.org/10.1016/j.jss.2010.07.019
Weil, Brent R. ; Manukyan, Mariuxi C. ; Herrmann, Jeremy L. ; Abarbanell, Aaron M. ; Poynter, Jeffrey A. ; Wang, Yue ; Meldrum, Daniel R. / The immunomodulatory properties of mesenchymal stem cells : Implications for surgical disease. In: Journal of Surgical Research. 2011 ; Vol. 167, No. 1. pp. 78-86.
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