The Impact of Genomic Profiling for Novel Cancer Therapy - Recent Progress in Non-Small Cell Lung Cancer

Jingwu Xie, Xiaoli Zhang

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

There is high expectation for significant improvements in cancer patient care after completion of the human genome project in 2003. Through pains-taking analyses of genomic profiles in cancer patients, a number of targetable gene alterations have been discovered, with some leading to novel therapies, such as activating mutations of EGFR, BRAF and ALK gene fusions. As a result, clinical management of cancer through targeted therapy has finally become a reality for a subset of cancers, such as lung adenocarcinomas and melanomas. In this review, we summarize how gene mutation discovery leads to new treatment strategies using non-small cell lung cancer (NSCLC) as an example. We also discuss possible future implications of cancer genome analyses.

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalJournal of Genetics and Genomics
Volume43
Issue number1
DOIs
StatePublished - Jan 20 2016

Keywords

  • Gene mutation
  • Lung cancer
  • Targeted therapy

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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