The impact of oculomotor functioning on neuropsychological performance in Huntington disease

Janessa O. Carvalho, Jeffrey D. Long, Holly J. Westervelt, Megan M. Smith, Jared M. Bruce, Ji In Kim, James A. Mills, Jane S. Paulsen, Isabella De Soriano, Courtney Shadrick, Amanda Miller, Edmond Chiu, Joy Preston, Anita Goh, Stephanie Antonopoulos, Samantha Loi, Phyllis Chua, Angela Komiti, Lynn Raymond, Joji Decolongon & 107 others Mannie Fan, Allison Coleman, Christopher A. Ross, Mark Varvaris, Maryjane Ong, Nadine Yoritomo, William M. Mallonee, Greg Suter, Ali Samii, Emily P. Freney, Alma Macaraeg, Randi Jones, Cathy Wood-Siverio, Stewart A. Factor, Roger A. Barker, Sarah Mason, Natalie Valle Guzman, Elizabeth McCusker, Jane Griffith, Clement Loy, Jillian McMillan, David Gunn, Michael Orth, Sigurd Süßmuth, Katrin Barth, Sonja Trautmann, Daniela Schwenk, Carolin Eschenbach, Kimberly Quaid, Melissa Wesson, Joanne Wojcieszek, Mark Guttman, Alanna Sheinberg, Albie Law, Irita Karmalkar, Susan Perlman, Brian Clemente, Michael D. Geschwind, Sharon Sha, Joseph Winer, Gabriela Satris, Tom Warner, Maggie Burrows, Anne Rosser, Kathy Price, Sarah Hunt, Frederick Marshall, Amy Chesire, Mary Wodarski, Charlyne Hickey, Peter Panegyres, Joseph Lee, Maria Tedesco, Brenton Maxwell, Joel Perlmutter, Stacey Barton, Shineeka Smith, Zosia Miedzybrodzka, Daniela Rae, Vivien Vaughan, Mariella D'Alessandro, David Craufurd, Judith Bek, Elizabeth Howard, Pietro Mazzoni, Karen Marder, Paula Wasserman, Rajeev Kumar, Diane Erickson, Christina Reeves, Breanna Nickels, Vicki Wheelock, Lisa Kjer, Amanda Martin, Sarah Farias, Wayne Martin, Oksana Suchowersky, Pamela King, Marguerite Wieler, Satwinder Sran, Anwar Ahmed, Stephen Rao, Christine Reece, Alex Bura, Lyla Mourany, Phil Danzer, Kelsey Montross, Deborah Harrington, Holly Westervalt, Elizabeth Aylward, David J. Moser, Janet Williams, Nancy Downing, Vincent A. Magnotta, Hans J. Johnson, Thomas Brashers-Krug, Jatin Vaidya, Daniel O'Leary, Eun Young Kim, Spencer Lourens, Ying Zhang, Wenjing Lu, Cheryl Erwin, Martha Nance, H. Jeremy Bockholt, Jason Evans, Roland Zschiegner

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalJournal of Clinical and Experimental Neuropsychology
Volume38
Issue number2
DOIs
StatePublished - Feb 7 2016

Fingerprint

Huntington Disease
Multiple Sclerosis
Psychiatry
Schizophrenia
Population

Keywords

  • Huntington disease
  • Neuropsychology
  • Oculomotor functioning
  • PREDICT-HD
  • Processing speed

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Clinical Psychology

Cite this

Carvalho, J. O., Long, J. D., Westervelt, H. J., Smith, M. M., Bruce, J. M., Kim, J. I., ... Zschiegner, R. (2016). The impact of oculomotor functioning on neuropsychological performance in Huntington disease. Journal of Clinical and Experimental Neuropsychology, 38(2), 217-226. https://doi.org/10.1080/13803395.2015.1101054

The impact of oculomotor functioning on neuropsychological performance in Huntington disease. / Carvalho, Janessa O.; Long, Jeffrey D.; Westervelt, Holly J.; Smith, Megan M.; Bruce, Jared M.; Kim, Ji In; Mills, James A.; Paulsen, Jane S.; De Soriano, Isabella; Shadrick, Courtney; Miller, Amanda; Chiu, Edmond; Preston, Joy; Goh, Anita; Antonopoulos, Stephanie; Loi, Samantha; Chua, Phyllis; Komiti, Angela; Raymond, Lynn; Decolongon, Joji; Fan, Mannie; Coleman, Allison; Ross, Christopher A.; Varvaris, Mark; Ong, Maryjane; Yoritomo, Nadine; Mallonee, William M.; Suter, Greg; Samii, Ali; Freney, Emily P.; Macaraeg, Alma; Jones, Randi; Wood-Siverio, Cathy; Factor, Stewart A.; Barker, Roger A.; Mason, Sarah; Guzman, Natalie Valle; McCusker, Elizabeth; Griffith, Jane; Loy, Clement; McMillan, Jillian; Gunn, David; Orth, Michael; Süßmuth, Sigurd; Barth, Katrin; Trautmann, Sonja; Schwenk, Daniela; Eschenbach, Carolin; Quaid, Kimberly; Wesson, Melissa; Wojcieszek, Joanne; Guttman, Mark; Sheinberg, Alanna; Law, Albie; Karmalkar, Irita; Perlman, Susan; Clemente, Brian; Geschwind, Michael D.; Sha, Sharon; Winer, Joseph; Satris, Gabriela; Warner, Tom; Burrows, Maggie; Rosser, Anne; Price, Kathy; Hunt, Sarah; Marshall, Frederick; Chesire, Amy; Wodarski, Mary; Hickey, Charlyne; Panegyres, Peter; Lee, Joseph; Tedesco, Maria; Maxwell, Brenton; Perlmutter, Joel; Barton, Stacey; Smith, Shineeka; Miedzybrodzka, Zosia; Rae, Daniela; Vaughan, Vivien; D'Alessandro, Mariella; Craufurd, David; Bek, Judith; Howard, Elizabeth; Mazzoni, Pietro; Marder, Karen; Wasserman, Paula; Kumar, Rajeev; Erickson, Diane; Reeves, Christina; Nickels, Breanna; Wheelock, Vicki; Kjer, Lisa; Martin, Amanda; Farias, Sarah; Martin, Wayne; Suchowersky, Oksana; King, Pamela; Wieler, Marguerite; Sran, Satwinder; Ahmed, Anwar; Rao, Stephen; Reece, Christine; Bura, Alex; Mourany, Lyla; Danzer, Phil; Montross, Kelsey; Harrington, Deborah; Westervalt, Holly; Aylward, Elizabeth; Moser, David J.; Williams, Janet; Downing, Nancy; Magnotta, Vincent A.; Johnson, Hans J.; Brashers-Krug, Thomas; Vaidya, Jatin; O'Leary, Daniel; Young Kim, Eun; Lourens, Spencer; Zhang, Ying; Lu, Wenjing; Erwin, Cheryl; Nance, Martha; Bockholt, H. Jeremy; Evans, Jason; Zschiegner, Roland.

In: Journal of Clinical and Experimental Neuropsychology, Vol. 38, No. 2, 07.02.2016, p. 217-226.

Research output: Contribution to journalArticle

Carvalho, JO, Long, JD, Westervelt, HJ, Smith, MM, Bruce, JM, Kim, JI, Mills, JA, Paulsen, JS, De Soriano, I, Shadrick, C, Miller, A, Chiu, E, Preston, J, Goh, A, Antonopoulos, S, Loi, S, Chua, P, Komiti, A, Raymond, L, Decolongon, J, Fan, M, Coleman, A, Ross, CA, Varvaris, M, Ong, M, Yoritomo, N, Mallonee, WM, Suter, G, Samii, A, Freney, EP, Macaraeg, A, Jones, R, Wood-Siverio, C, Factor, SA, Barker, RA, Mason, S, Guzman, NV, McCusker, E, Griffith, J, Loy, C, McMillan, J, Gunn, D, Orth, M, Süßmuth, S, Barth, K, Trautmann, S, Schwenk, D, Eschenbach, C, Quaid, K, Wesson, M, Wojcieszek, J, Guttman, M, Sheinberg, A, Law, A, Karmalkar, I, Perlman, S, Clemente, B, Geschwind, MD, Sha, S, Winer, J, Satris, G, Warner, T, Burrows, M, Rosser, A, Price, K, Hunt, S, Marshall, F, Chesire, A, Wodarski, M, Hickey, C, Panegyres, P, Lee, J, Tedesco, M, Maxwell, B, Perlmutter, J, Barton, S, Smith, S, Miedzybrodzka, Z, Rae, D, Vaughan, V, D'Alessandro, M, Craufurd, D, Bek, J, Howard, E, Mazzoni, P, Marder, K, Wasserman, P, Kumar, R, Erickson, D, Reeves, C, Nickels, B, Wheelock, V, Kjer, L, Martin, A, Farias, S, Martin, W, Suchowersky, O, King, P, Wieler, M, Sran, S, Ahmed, A, Rao, S, Reece, C, Bura, A, Mourany, L, Danzer, P, Montross, K, Harrington, D, Westervalt, H, Aylward, E, Moser, DJ, Williams, J, Downing, N, Magnotta, VA, Johnson, HJ, Brashers-Krug, T, Vaidya, J, O'Leary, D, Young Kim, E, Lourens, S, Zhang, Y, Lu, W, Erwin, C, Nance, M, Bockholt, HJ, Evans, J & Zschiegner, R 2016, 'The impact of oculomotor functioning on neuropsychological performance in Huntington disease', Journal of Clinical and Experimental Neuropsychology, vol. 38, no. 2, pp. 217-226. https://doi.org/10.1080/13803395.2015.1101054
Carvalho, Janessa O. ; Long, Jeffrey D. ; Westervelt, Holly J. ; Smith, Megan M. ; Bruce, Jared M. ; Kim, Ji In ; Mills, James A. ; Paulsen, Jane S. ; De Soriano, Isabella ; Shadrick, Courtney ; Miller, Amanda ; Chiu, Edmond ; Preston, Joy ; Goh, Anita ; Antonopoulos, Stephanie ; Loi, Samantha ; Chua, Phyllis ; Komiti, Angela ; Raymond, Lynn ; Decolongon, Joji ; Fan, Mannie ; Coleman, Allison ; Ross, Christopher A. ; Varvaris, Mark ; Ong, Maryjane ; Yoritomo, Nadine ; Mallonee, William M. ; Suter, Greg ; Samii, Ali ; Freney, Emily P. ; Macaraeg, Alma ; Jones, Randi ; Wood-Siverio, Cathy ; Factor, Stewart A. ; Barker, Roger A. ; Mason, Sarah ; Guzman, Natalie Valle ; McCusker, Elizabeth ; Griffith, Jane ; Loy, Clement ; McMillan, Jillian ; Gunn, David ; Orth, Michael ; Süßmuth, Sigurd ; Barth, Katrin ; Trautmann, Sonja ; Schwenk, Daniela ; Eschenbach, Carolin ; Quaid, Kimberly ; Wesson, Melissa ; Wojcieszek, Joanne ; Guttman, Mark ; Sheinberg, Alanna ; Law, Albie ; Karmalkar, Irita ; Perlman, Susan ; Clemente, Brian ; Geschwind, Michael D. ; Sha, Sharon ; Winer, Joseph ; Satris, Gabriela ; Warner, Tom ; Burrows, Maggie ; Rosser, Anne ; Price, Kathy ; Hunt, Sarah ; Marshall, Frederick ; Chesire, Amy ; Wodarski, Mary ; Hickey, Charlyne ; Panegyres, Peter ; Lee, Joseph ; Tedesco, Maria ; Maxwell, Brenton ; Perlmutter, Joel ; Barton, Stacey ; Smith, Shineeka ; Miedzybrodzka, Zosia ; Rae, Daniela ; Vaughan, Vivien ; D'Alessandro, Mariella ; Craufurd, David ; Bek, Judith ; Howard, Elizabeth ; Mazzoni, Pietro ; Marder, Karen ; Wasserman, Paula ; Kumar, Rajeev ; Erickson, Diane ; Reeves, Christina ; Nickels, Breanna ; Wheelock, Vicki ; Kjer, Lisa ; Martin, Amanda ; Farias, Sarah ; Martin, Wayne ; Suchowersky, Oksana ; King, Pamela ; Wieler, Marguerite ; Sran, Satwinder ; Ahmed, Anwar ; Rao, Stephen ; Reece, Christine ; Bura, Alex ; Mourany, Lyla ; Danzer, Phil ; Montross, Kelsey ; Harrington, Deborah ; Westervalt, Holly ; Aylward, Elizabeth ; Moser, David J. ; Williams, Janet ; Downing, Nancy ; Magnotta, Vincent A. ; Johnson, Hans J. ; Brashers-Krug, Thomas ; Vaidya, Jatin ; O'Leary, Daniel ; Young Kim, Eun ; Lourens, Spencer ; Zhang, Ying ; Lu, Wenjing ; Erwin, Cheryl ; Nance, Martha ; Bockholt, H. Jeremy ; Evans, Jason ; Zschiegner, Roland. / The impact of oculomotor functioning on neuropsychological performance in Huntington disease. In: Journal of Clinical and Experimental Neuropsychology. 2016 ; Vol. 38, No. 2. pp. 217-226.
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