The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood

COGA Investigators

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Heavy episodic drinking is developmentally normative among adolescents and young adults, but is linked to adverse consequences in later life, such as drug and alcohol dependence. Genetic and peer influences are robust predictors of heavy episodic drinking in youth, but little is known about the interplay between polygenic risk and peer influences as they impact developmental patterns of heavy episodic drinking. Methods: Data were from a multisite prospective study of alcohol use among adolescents and young adults with genome-wide association data (n = 412). Generalized linear mixed models were used to characterize the initial status and slopes of heavy episodic drinking between age 15 and 28. Polygenic risk scores (PRS) were derived from a separate genome-wide association study for alcohol dependence and examined for their interaction with substance use among the adolescents’ closest friends in predicting the initial status and slopes of heavy episodic drinking. Results: Close friend substance use was a robust predictor of adolescent heavy episodic drinking, even after controlling for parental knowledge and peer substance use in the school. PRS were predictive of the initial status and early patterns of heavy episodic drinking in males, but not in females. No interaction was detected between PRS and close friend substance use for heavy episodic drinking trajectories in either males or females. Conclusions: Although substance use among close friends and genetic influences play an important role in predicting heavy episodic drinking trajectories, particularly during the late adolescent to early adult years, we found no evidence of interaction between these influences after controlling for other social processes, such as parental knowledge and broader substance use among other peers outside of close friends. The use of longitudinal models and accounting for multiple social influences may be crucial for future studies focused on uncovering gene–environment interplay. Clinical implications are also discussed.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalAlcoholism: Clinical and Experimental Research
Volume41
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Drinking
Trajectories
Alcohols
Genes
Alcoholism
Young Adult
Genome-Wide Association Study
Pharmaceutical Preparations
Substance-Related Disorders
Linear Models
Genome
Prospective Studies

Keywords

  • Development
  • Gene–Environment Interaction
  • Heavy Episodic Drinking
  • Peer Influences
  • Polygenic Risk Score

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

@article{30bc4e0f1c2c41d4802aadb011c34f75,
title = "The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood",
abstract = "Background: Heavy episodic drinking is developmentally normative among adolescents and young adults, but is linked to adverse consequences in later life, such as drug and alcohol dependence. Genetic and peer influences are robust predictors of heavy episodic drinking in youth, but little is known about the interplay between polygenic risk and peer influences as they impact developmental patterns of heavy episodic drinking. Methods: Data were from a multisite prospective study of alcohol use among adolescents and young adults with genome-wide association data (n = 412). Generalized linear mixed models were used to characterize the initial status and slopes of heavy episodic drinking between age 15 and 28. Polygenic risk scores (PRS) were derived from a separate genome-wide association study for alcohol dependence and examined for their interaction with substance use among the adolescents’ closest friends in predicting the initial status and slopes of heavy episodic drinking. Results: Close friend substance use was a robust predictor of adolescent heavy episodic drinking, even after controlling for parental knowledge and peer substance use in the school. PRS were predictive of the initial status and early patterns of heavy episodic drinking in males, but not in females. No interaction was detected between PRS and close friend substance use for heavy episodic drinking trajectories in either males or females. Conclusions: Although substance use among close friends and genetic influences play an important role in predicting heavy episodic drinking trajectories, particularly during the late adolescent to early adult years, we found no evidence of interaction between these influences after controlling for other social processes, such as parental knowledge and broader substance use among other peers outside of close friends. The use of longitudinal models and accounting for multiple social influences may be crucial for future studies focused on uncovering gene–environment interplay. Clinical implications are also discussed.",
keywords = "Development, Gene–Environment Interaction, Heavy Episodic Drinking, Peer Influences, Polygenic Risk Score",
author = "{COGA Investigators} and Li, {James J.} and Cho, {Seung Bin} and Salvatore, {Jessica E.} and Howard Edenberg and Arpana Agrawal and Chorlian, {David B.} and Bernice Porjesz and Victor Hesselbrock and Dick, {Danielle M.} and H. Edenberg and L. Bierut and John Nurnberger and Tatiana Foroud and S. Kuperman and J. Kramer and A. Goate and J. Rice and K. Bucholz and M. Schuckit and J. Tischfield and L. Almasy and R. Taylor and D. Dick and L. Bauer and D. Koller and Sean O'Connor and L. Wetherill and Xiaoling Xuei and Grace Chan and S. Kang and N. Manz and Wang, {J. C.} and A. Brooks and F. Aliev and A. Parsian and M. Reilly",
year = "2017",
month = "1",
day = "1",
doi = "10.1111/acer.13282",
language = "English (US)",
volume = "41",
pages = "65--75",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood

AU - COGA Investigators

AU - Li, James J.

AU - Cho, Seung Bin

AU - Salvatore, Jessica E.

AU - Edenberg, Howard

AU - Agrawal, Arpana

AU - Chorlian, David B.

AU - Porjesz, Bernice

AU - Hesselbrock, Victor

AU - Dick, Danielle M.

AU - Edenberg, H.

AU - Bierut, L.

AU - Nurnberger, John

AU - Foroud, Tatiana

AU - Kuperman, S.

AU - Kramer, J.

AU - Goate, A.

AU - Rice, J.

AU - Bucholz, K.

AU - Schuckit, M.

AU - Tischfield, J.

AU - Almasy, L.

AU - Taylor, R.

AU - Dick, D.

AU - Bauer, L.

AU - Koller, D.

AU - O'Connor, Sean

AU - Wetherill, L.

AU - Xuei, Xiaoling

AU - Chan, Grace

AU - Kang, S.

AU - Manz, N.

AU - Wang, J. C.

AU - Brooks, A.

AU - Aliev, F.

AU - Parsian, A.

AU - Reilly, M.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Heavy episodic drinking is developmentally normative among adolescents and young adults, but is linked to adverse consequences in later life, such as drug and alcohol dependence. Genetic and peer influences are robust predictors of heavy episodic drinking in youth, but little is known about the interplay between polygenic risk and peer influences as they impact developmental patterns of heavy episodic drinking. Methods: Data were from a multisite prospective study of alcohol use among adolescents and young adults with genome-wide association data (n = 412). Generalized linear mixed models were used to characterize the initial status and slopes of heavy episodic drinking between age 15 and 28. Polygenic risk scores (PRS) were derived from a separate genome-wide association study for alcohol dependence and examined for their interaction with substance use among the adolescents’ closest friends in predicting the initial status and slopes of heavy episodic drinking. Results: Close friend substance use was a robust predictor of adolescent heavy episodic drinking, even after controlling for parental knowledge and peer substance use in the school. PRS were predictive of the initial status and early patterns of heavy episodic drinking in males, but not in females. No interaction was detected between PRS and close friend substance use for heavy episodic drinking trajectories in either males or females. Conclusions: Although substance use among close friends and genetic influences play an important role in predicting heavy episodic drinking trajectories, particularly during the late adolescent to early adult years, we found no evidence of interaction between these influences after controlling for other social processes, such as parental knowledge and broader substance use among other peers outside of close friends. The use of longitudinal models and accounting for multiple social influences may be crucial for future studies focused on uncovering gene–environment interplay. Clinical implications are also discussed.

AB - Background: Heavy episodic drinking is developmentally normative among adolescents and young adults, but is linked to adverse consequences in later life, such as drug and alcohol dependence. Genetic and peer influences are robust predictors of heavy episodic drinking in youth, but little is known about the interplay between polygenic risk and peer influences as they impact developmental patterns of heavy episodic drinking. Methods: Data were from a multisite prospective study of alcohol use among adolescents and young adults with genome-wide association data (n = 412). Generalized linear mixed models were used to characterize the initial status and slopes of heavy episodic drinking between age 15 and 28. Polygenic risk scores (PRS) were derived from a separate genome-wide association study for alcohol dependence and examined for their interaction with substance use among the adolescents’ closest friends in predicting the initial status and slopes of heavy episodic drinking. Results: Close friend substance use was a robust predictor of adolescent heavy episodic drinking, even after controlling for parental knowledge and peer substance use in the school. PRS were predictive of the initial status and early patterns of heavy episodic drinking in males, but not in females. No interaction was detected between PRS and close friend substance use for heavy episodic drinking trajectories in either males or females. Conclusions: Although substance use among close friends and genetic influences play an important role in predicting heavy episodic drinking trajectories, particularly during the late adolescent to early adult years, we found no evidence of interaction between these influences after controlling for other social processes, such as parental knowledge and broader substance use among other peers outside of close friends. The use of longitudinal models and accounting for multiple social influences may be crucial for future studies focused on uncovering gene–environment interplay. Clinical implications are also discussed.

KW - Development

KW - Gene–Environment Interaction

KW - Heavy Episodic Drinking

KW - Peer Influences

KW - Polygenic Risk Score

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U2 - 10.1111/acer.13282

DO - 10.1111/acer.13282

M3 - Article

C2 - 27991676

AN - SCOPUS:85007010360

VL - 41

SP - 65

EP - 75

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 1

ER -