The impact of the perimetric measurement scale, sample composition, and statistical method on the structure-function relationship in glaucoma

Lyne Racette, Felipe A. Medeiros, Christopher Bowd, Linda M. Zangwill, Robert N. Weinreb, Pamela A. Sample

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

PURPOSE: To investigate the impact of perimetric measurement scales, sample composition, and 2 statistical methods on the structure-function relationship in glaucoma. METHODS: Three hundred eighty-five eyes of 385 participants, covering the full spectrum of the disease from healthy to advanced glaucoma, were tested with the Heidelberg Retina Tomograph and standard automated perimetry (Swedish Interactive Thresholding Algorithm) within a 6-month period. The associations (R) between neuroretinal rim area and perimetric data expressed in logarithmic (dB) and linear (1/Lambert) units were measured for linear and curvilinear (quadratic and logarithmic) models. The best-fit model resulting from 2 statistical analyses (χ coefficient and analysis of the residuals) were compared in the visual field areas corresponding to the 6 Heidelberg Retina Tomograph sectors and in the central visual field. These analyses were performed on the complete sample and on a subset of the study population composed only of healthy controls and patients with definite glaucoma. RESULTS: The R values ranged from 0.01 to 0.32 with the strongest associations in the supero-temporal and infero-temporal optic disc regions. When perimetric data were expressed in dB units, the curvilinear models generally explained more variance than the linear model. When perimetric data were expressed in 1/Lambert units, differences were observed between the 2 statistical and subgroup analyses. CONCLUSIONS: The perimetric measurement scale is one of many factors influencing the structure-function relationship. It is also influenced by the composition of the sample and by the statistical method of analysis. Expressing perimetric data in linear units does not always translate into linear structure-function relationships.

Original languageEnglish (US)
Pages (from-to)676-684
Number of pages9
JournalJournal of Glaucoma
Volume16
Issue number8
DOIs
StatePublished - Dec 1 2007

Fingerprint

Glaucoma
Visual Fields
Retina
Visual Field Tests
Optic Disk
Linear Models
Population

Keywords

  • Glaucoma
  • Measurement scale
  • Structure-function relationship

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The impact of the perimetric measurement scale, sample composition, and statistical method on the structure-function relationship in glaucoma. / Racette, Lyne; Medeiros, Felipe A.; Bowd, Christopher; Zangwill, Linda M.; Weinreb, Robert N.; Sample, Pamela A.

In: Journal of Glaucoma, Vol. 16, No. 8, 01.12.2007, p. 676-684.

Research output: Contribution to journalArticle

Racette, Lyne ; Medeiros, Felipe A. ; Bowd, Christopher ; Zangwill, Linda M. ; Weinreb, Robert N. ; Sample, Pamela A. / The impact of the perimetric measurement scale, sample composition, and statistical method on the structure-function relationship in glaucoma. In: Journal of Glaucoma. 2007 ; Vol. 16, No. 8. pp. 676-684.
@article{8877dea7229246b9961e6af734518691,
title = "The impact of the perimetric measurement scale, sample composition, and statistical method on the structure-function relationship in glaucoma",
abstract = "PURPOSE: To investigate the impact of perimetric measurement scales, sample composition, and 2 statistical methods on the structure-function relationship in glaucoma. METHODS: Three hundred eighty-five eyes of 385 participants, covering the full spectrum of the disease from healthy to advanced glaucoma, were tested with the Heidelberg Retina Tomograph and standard automated perimetry (Swedish Interactive Thresholding Algorithm) within a 6-month period. The associations (R) between neuroretinal rim area and perimetric data expressed in logarithmic (dB) and linear (1/Lambert) units were measured for linear and curvilinear (quadratic and logarithmic) models. The best-fit model resulting from 2 statistical analyses (χ coefficient and analysis of the residuals) were compared in the visual field areas corresponding to the 6 Heidelberg Retina Tomograph sectors and in the central visual field. These analyses were performed on the complete sample and on a subset of the study population composed only of healthy controls and patients with definite glaucoma. RESULTS: The R values ranged from 0.01 to 0.32 with the strongest associations in the supero-temporal and infero-temporal optic disc regions. When perimetric data were expressed in dB units, the curvilinear models generally explained more variance than the linear model. When perimetric data were expressed in 1/Lambert units, differences were observed between the 2 statistical and subgroup analyses. CONCLUSIONS: The perimetric measurement scale is one of many factors influencing the structure-function relationship. It is also influenced by the composition of the sample and by the statistical method of analysis. Expressing perimetric data in linear units does not always translate into linear structure-function relationships.",
keywords = "Glaucoma, Measurement scale, Structure-function relationship",
author = "Lyne Racette and Medeiros, {Felipe A.} and Christopher Bowd and Zangwill, {Linda M.} and Weinreb, {Robert N.} and Sample, {Pamela A.}",
year = "2007",
month = "12",
day = "1",
doi = "10.1097/IJG.0b013e31804d23c2",
language = "English (US)",
volume = "16",
pages = "676--684",
journal = "Journal of Glaucoma",
issn = "1057-0829",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - The impact of the perimetric measurement scale, sample composition, and statistical method on the structure-function relationship in glaucoma

AU - Racette, Lyne

AU - Medeiros, Felipe A.

AU - Bowd, Christopher

AU - Zangwill, Linda M.

AU - Weinreb, Robert N.

AU - Sample, Pamela A.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - PURPOSE: To investigate the impact of perimetric measurement scales, sample composition, and 2 statistical methods on the structure-function relationship in glaucoma. METHODS: Three hundred eighty-five eyes of 385 participants, covering the full spectrum of the disease from healthy to advanced glaucoma, were tested with the Heidelberg Retina Tomograph and standard automated perimetry (Swedish Interactive Thresholding Algorithm) within a 6-month period. The associations (R) between neuroretinal rim area and perimetric data expressed in logarithmic (dB) and linear (1/Lambert) units were measured for linear and curvilinear (quadratic and logarithmic) models. The best-fit model resulting from 2 statistical analyses (χ coefficient and analysis of the residuals) were compared in the visual field areas corresponding to the 6 Heidelberg Retina Tomograph sectors and in the central visual field. These analyses were performed on the complete sample and on a subset of the study population composed only of healthy controls and patients with definite glaucoma. RESULTS: The R values ranged from 0.01 to 0.32 with the strongest associations in the supero-temporal and infero-temporal optic disc regions. When perimetric data were expressed in dB units, the curvilinear models generally explained more variance than the linear model. When perimetric data were expressed in 1/Lambert units, differences were observed between the 2 statistical and subgroup analyses. CONCLUSIONS: The perimetric measurement scale is one of many factors influencing the structure-function relationship. It is also influenced by the composition of the sample and by the statistical method of analysis. Expressing perimetric data in linear units does not always translate into linear structure-function relationships.

AB - PURPOSE: To investigate the impact of perimetric measurement scales, sample composition, and 2 statistical methods on the structure-function relationship in glaucoma. METHODS: Three hundred eighty-five eyes of 385 participants, covering the full spectrum of the disease from healthy to advanced glaucoma, were tested with the Heidelberg Retina Tomograph and standard automated perimetry (Swedish Interactive Thresholding Algorithm) within a 6-month period. The associations (R) between neuroretinal rim area and perimetric data expressed in logarithmic (dB) and linear (1/Lambert) units were measured for linear and curvilinear (quadratic and logarithmic) models. The best-fit model resulting from 2 statistical analyses (χ coefficient and analysis of the residuals) were compared in the visual field areas corresponding to the 6 Heidelberg Retina Tomograph sectors and in the central visual field. These analyses were performed on the complete sample and on a subset of the study population composed only of healthy controls and patients with definite glaucoma. RESULTS: The R values ranged from 0.01 to 0.32 with the strongest associations in the supero-temporal and infero-temporal optic disc regions. When perimetric data were expressed in dB units, the curvilinear models generally explained more variance than the linear model. When perimetric data were expressed in 1/Lambert units, differences were observed between the 2 statistical and subgroup analyses. CONCLUSIONS: The perimetric measurement scale is one of many factors influencing the structure-function relationship. It is also influenced by the composition of the sample and by the statistical method of analysis. Expressing perimetric data in linear units does not always translate into linear structure-function relationships.

KW - Glaucoma

KW - Measurement scale

KW - Structure-function relationship

UR - http://www.scopus.com/inward/record.url?scp=37349027519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37349027519&partnerID=8YFLogxK

U2 - 10.1097/IJG.0b013e31804d23c2

DO - 10.1097/IJG.0b013e31804d23c2

M3 - Article

C2 - 18091454

AN - SCOPUS:37349027519

VL - 16

SP - 676

EP - 684

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 8

ER -