From 1971-1986, peritoneal washings were obtained for cytologic examination at the time of primary exploratory laparotomy in 340 patients with endometrial adenocarcinoma. Seventy-two samples (21.2%) contained malignant cells. The finding of malignant cytology increased with stage of disease: Stage I, 17%; stage II, 19.5%; stage III, 68.7%; and stage IV, 85.7% (P<.001). In 248 patients with clinical stage I disease for whom uterine evaluation was complete, there was an increasing incidence of malignant cytology with increasing grade (P=.002), depth of myometrial invasion (P=.003), and adnexal spread (P<.001). Twelve of 41 patients (29.3%) with clinical stage I and positive cytology developed recurrent disease, compared with six of 207 (2.9%) with negative cytology (P<.001). Survival for all stages together was poorer in patients with positive washings than in those with negative washings (P<.001). This difference in survival was also observed in patients with clinical stage I disease (P<.001). Among patients with surgical stage I disease, disease-free survival was also superior in the group with negative cytology. In both clinical and surgical stage I, intra-abdominal recurrences were more common among patients with malignant peritoneal cytology.
|Original language||English (US)|
|Number of pages||5|
|Journal||Obstetrics and gynecology|
|State||Published - Sep 1988|
ASJC Scopus subject areas
- Obstetrics and Gynecology