The importance of peritoneal cytology in endometrial carcinoma

Victor R. Harouny, Gregory P. Sutton, Stephen A. Clark, Hans E. Geisler, Frederick Stehman, Clarence E. Ehrlich

Research output: Contribution to journalArticle

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Abstract

From 1971-1986, peritoneal washings were obtained for cytologic examination at the time of primary exploratory laparotomy in 340 patients with endometrial adenocarcinoma. Seventy-two samples (21.2%) contained malignant cells. The finding of malignant cytology increased with stage of disease: Stage I, 17%; stage II, 19.5%; stage III, 68.7%; and stage IV, 85.7% (P<.001). In 248 patients with clinical stage I disease for whom uterine evaluation was complete, there was an increasing incidence of malignant cytology with increasing grade (P=.002), depth of myometrial invasion (P=.003), and adnexal spread (P<.001). Twelve of 41 patients (29.3%) with clinical stage I and positive cytology developed recurrent disease, compared with six of 207 (2.9%) with negative cytology (P<.001). Survival for all stages together was poorer in patients with positive washings than in those with negative washings (P<.001). This difference in survival was also observed in patients with clinical stage I disease (P<.001). Among patients with surgical stage I disease, disease-free survival was also superior in the group with negative cytology. In both clinical and surgical stage I, intra-abdominal recurrences were more common among patients with malignant peritoneal cytology.

Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalObstetrics and Gynecology
Volume72
Issue number3
StatePublished - 1988

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Endometrial Neoplasms
Cell Biology
Uterine Diseases
Survival
Laparotomy
Disease-Free Survival
Adenocarcinoma
Recurrence
Incidence

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Harouny, V. R., Sutton, G. P., Clark, S. A., Geisler, H. E., Stehman, F., & Ehrlich, C. E. (1988). The importance of peritoneal cytology in endometrial carcinoma. Obstetrics and Gynecology, 72(3), 394-398.

The importance of peritoneal cytology in endometrial carcinoma. / Harouny, Victor R.; Sutton, Gregory P.; Clark, Stephen A.; Geisler, Hans E.; Stehman, Frederick; Ehrlich, Clarence E.

In: Obstetrics and Gynecology, Vol. 72, No. 3, 1988, p. 394-398.

Research output: Contribution to journalArticle

Harouny, VR, Sutton, GP, Clark, SA, Geisler, HE, Stehman, F & Ehrlich, CE 1988, 'The importance of peritoneal cytology in endometrial carcinoma', Obstetrics and Gynecology, vol. 72, no. 3, pp. 394-398.
Harouny VR, Sutton GP, Clark SA, Geisler HE, Stehman F, Ehrlich CE. The importance of peritoneal cytology in endometrial carcinoma. Obstetrics and Gynecology. 1988;72(3):394-398.
Harouny, Victor R. ; Sutton, Gregory P. ; Clark, Stephen A. ; Geisler, Hans E. ; Stehman, Frederick ; Ehrlich, Clarence E. / The importance of peritoneal cytology in endometrial carcinoma. In: Obstetrics and Gynecology. 1988 ; Vol. 72, No. 3. pp. 394-398.
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