The distribution of the genetic polymorphism for CYP2C19 in Asians seems different from that in Caucasians. No distribution of the mutations in CYP2C19 or CYP2C9 has been published in a Korean population. We determined the genotypes of 143 healthy, Korean volunteers for CYP2C19 (m1 and m2 mutations) and CYP2C9 (v1 mutation), and compared that to the distribution in a Caucasian population. The m1 and m2 mutations of CYP2C19 appear in significantly greater incidence in this Korean population than Caucasians (p<0.005), but the incidence of the v1 mutation of 2C9 is less in Koreans: P450 Genotypes Korean USA CYP2C19 m1/m1 0.13 0.09 m1/wt 0.39 0.28 m2/m2 0.01 0.00 m2/wt 0.28 0.12 m1/wt and m2/wt 0.09 0.00 CYP2C9 wt/wt 1.00 0.81 v1/v1 0.00 0.01 v1/wt 0.00 0.18 These data suggest that the incidence of Korean genetic poor metabolizers of CYP2C19 (0.22) is relatively large and that the v1 mutation of CYP2C9 is not prominent in Koreans.
|Original language||English (US)|
|Number of pages||1|
|Journal||Clinical Pharmacology and Therapeutics|
|State||Published - Dec 1 1997|
ASJC Scopus subject areas
- Pharmacology (medical)