The independent correlation between high-density lipoprotein cholesterol and subsequent major adverse coronary events

Carol E. Koro, Steven J. Bowlin, Timothy E. Stump, Dennis L. Sprecher, William M. Tierney

Research output: Contribution to journalArticle

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Abstract

Background: There is substantial evidence from clinical trials that lowering low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular risk. There is less evidence for the salutatory effects of raising high-density lipoprotein cholesterol (HDL-C). The predictive strength of an initial HDL-C measurement and its change over time for major adverse coronary events is not well understood. Methods: We identified a cohort of all 6928 patients in an urban primary care practice who had two or more lipid measurements between January 1985 and December 1997. We used bivariable and multivariable (Cox proportional hazards) techniques to identify independent predictors of subsequent major adverse coronary events (hospitalization for myocardial infarction or acute coronary syndrome) after the second set of lipid measurements. Results: The time between first and second lipid measurements averaged 2.6 years. During a mean of 5.1 ± 3.2 years of observation after their second lipid measurements, 2167 (31%) patients had an acute coronary event. Patients having events were significantly older, more often white, male, and smokers and more often had antecedent diabetes, hypertension, coronary heart disease, and myocardial infarctions. Adjusting for covariates, a 10-mg/dL higher initial HDL-C was associated with an 11% (95% CI 7%-14%) lower risk of coronary events. A 10-mg/dL increase in HDL-C between lipid measurements was associated with a 7% (95% CI 3%-10%) lower risk of events. Neither initial or change in triglycerides nor LDL-C predicted subsequent coronary events. Conclusion: High-density lipoprotein cholesterol measurements and change in HDL-C predicted major adverse coronary events in this urban practice, which provides support studying interventions targeting HDL-C for cardiovascular risk reduction.

Original languageEnglish
JournalAmerican Heart Journal
Volume151
Issue number3
DOIs
StatePublished - Mar 2006

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HDL Cholesterol
Lipids
LDL Cholesterol
Myocardial Infarction
Risk Reduction Behavior
Acute Coronary Syndrome
Coronary Disease
Primary Health Care
Triglycerides
Hospitalization
Observation
Clinical Trials
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The independent correlation between high-density lipoprotein cholesterol and subsequent major adverse coronary events. / Koro, Carol E.; Bowlin, Steven J.; Stump, Timothy E.; Sprecher, Dennis L.; Tierney, William M.

In: American Heart Journal, Vol. 151, No. 3, 03.2006.

Research output: Contribution to journalArticle

Koro, Carol E. ; Bowlin, Steven J. ; Stump, Timothy E. ; Sprecher, Dennis L. ; Tierney, William M. / The independent correlation between high-density lipoprotein cholesterol and subsequent major adverse coronary events. In: American Heart Journal. 2006 ; Vol. 151, No. 3.
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