The indusium griseum

Anatomic study with potential application to callosotomy

R. Shane Tubbs, Matthew Prekupec, Marios Loukas, Eyas M. Hattab, Aaron Cohen-Gadol

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Although the indusium griseum (IG) is often seen by the neurosurgeon, almost nothing exists in the literature regarding its anatomic structure. Some have postulated that this structure is a remnant of the hippocampus, and some have found memory deficits in patients after callosotomy. Objective: To further investigate the anatomy of the IG in humans through gross and histological analysis. Methods: The IG from 10 adult cadaveric brains underwent microdissection and immunohistochemical analysis. Results: Grossly, the IG was on average 2 cm in width over the body and genu of the corpus callosum (CC) and traveled in intimate contact anteriorly over the lamina terminalis, and posteriorly it was adherent to the splenium of the CC. Histologically, the IG is a thin layer of hypocellular glial tissue interposed between the pia and the CC. Glial cells composed the cellular constituents of the IG, and compared with the underlying CC, the IG was hypomyelinated. The fibers/axons of the IG travel in a perpendicular plane compared with those of the CC, and the IG varied in thickness from one area to the other and was occasionally discontinuous. Conclusion: The IG is a glial membrane with no neuronal content or obvious connections to the hippocampus. Based on this study, transection of this membrane with callosotomy should not be the reason for postoperative memory loss seen in some of these patients. Future studies aimed at elucidating the function of the IG in humans are now warranted.

Original languageEnglish
Pages (from-to)312-315
Number of pages4
JournalNeurosurgery
Volume73
Issue number2
DOIs
StatePublished - Aug 2013

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Corpus Callosum
Neuroglia
Memory Disorders
Hippocampus
Limbic Lobe
Microdissection
Membranes
Hypothalamus
Axons
Anatomy
Brain

Keywords

  • Anatomy
  • Callosotomy
  • Memory
  • Neuroanatomy
  • Neurosurgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

The indusium griseum : Anatomic study with potential application to callosotomy. / Tubbs, R. Shane; Prekupec, Matthew; Loukas, Marios; Hattab, Eyas M.; Cohen-Gadol, Aaron.

In: Neurosurgery, Vol. 73, No. 2, 08.2013, p. 312-315.

Research output: Contribution to journalArticle

Tubbs, R. Shane ; Prekupec, Matthew ; Loukas, Marios ; Hattab, Eyas M. ; Cohen-Gadol, Aaron. / The indusium griseum : Anatomic study with potential application to callosotomy. In: Neurosurgery. 2013 ; Vol. 73, No. 2. pp. 312-315.
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