The influence of age on bone mineral regulating hormones

S. Epstein, G. Bryce, J. W. Hinman, O. N. Miller, B. L. Riggs, Siu Hui, C. C. Johnston

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

The objective of this study was to determine the effect of age on the blood levels of 1,25-dihydroxyvitamin D (1,25(OH)2D) and immunoreactive parathyroid hormone (iPTH) in normal, healthy males and females. A total of 855 normal subjects (361 males and 494 females) were studied. The results show that for healthy males, blood concentrations of 1,25(OH)2D remained essentially constant with increasing age up to age 65, and then the concentrations decreased significantly. For healthy females, 1,25(OH)2D increased up to age 65, and then decreased at a significant rate. Serum iPTH in males increased with advancing age, but the rate of increase was greater after age 65. In females a significant increase in iPTH concentrations did not occur until after age 65. Serum creatinine increased in both males and females with advancing age.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalBone
Volume7
Issue number6
DOIs
StatePublished - 1986

Fingerprint

Minerals
Hormones
Bone and Bones
Parathyroid Hormone
Serum
Creatinine

Keywords

  • 1,25(OH)D
  • Aging
  • Bone Mineral Metabolism
  • Osteoporosis
  • Parathyroid Hormone

ASJC Scopus subject areas

  • Physiology
  • Hematology

Cite this

Epstein, S., Bryce, G., Hinman, J. W., Miller, O. N., Riggs, B. L., Hui, S., & Johnston, C. C. (1986). The influence of age on bone mineral regulating hormones. Bone, 7(6), 421-425. https://doi.org/10.1016/8756-3282(86)90001-3

The influence of age on bone mineral regulating hormones. / Epstein, S.; Bryce, G.; Hinman, J. W.; Miller, O. N.; Riggs, B. L.; Hui, Siu; Johnston, C. C.

In: Bone, Vol. 7, No. 6, 1986, p. 421-425.

Research output: Contribution to journalArticle

Epstein, S, Bryce, G, Hinman, JW, Miller, ON, Riggs, BL, Hui, S & Johnston, CC 1986, 'The influence of age on bone mineral regulating hormones', Bone, vol. 7, no. 6, pp. 421-425. https://doi.org/10.1016/8756-3282(86)90001-3
Epstein S, Bryce G, Hinman JW, Miller ON, Riggs BL, Hui S et al. The influence of age on bone mineral regulating hormones. Bone. 1986;7(6):421-425. https://doi.org/10.1016/8756-3282(86)90001-3
Epstein, S. ; Bryce, G. ; Hinman, J. W. ; Miller, O. N. ; Riggs, B. L. ; Hui, Siu ; Johnston, C. C. / The influence of age on bone mineral regulating hormones. In: Bone. 1986 ; Vol. 7, No. 6. pp. 421-425.
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