The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1

Jay M. Sosenko, Susan Geyer, Jay S. Skyler, Lisa E. Rafkin, Heba M. Ismail, Ingrid M. Libman, Yuk Fun Liu, Linda DiMeglio, Carmella Evans-Molina, Jerry P. Palmer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/Objective: The extent of influence of BMI and age on C-peptide at the diagnosis of type 1 diabetes (T1D) is unknown. We thus studied the impact of body mass index Z-scores (BMIZ) and age on C-peptide measures at and soon after the diagnosis of T1D. Methods: Data from Diabetes Prevention Trial-Type 1 (DPT-1) participants <18.0 years at diagnosis was analyzed. Analyses examined associations of C-peptide measures with BMIZ and age in 2 cohorts: oral glucose tolerance tests (OGTTs) at diagnosis (n = 99) and mixed meal tolerance tests (MMTTs) <6 months after diagnosis (n = 80). Multivariable linear regression was utilized. Results: Fasting and area under the curve (AUC) C-peptide from OGTTs (n = 99) at diagnosis and MMTTs (n = 80) after diagnosis were positively associated with BMIZ and age (P <.001 for all). Associations persisted when BMIZ and age were included as independent variables in regression models (P <.001 for all). BMIZ and age explained 31%-47% of the variance of C-peptide measures. In an example, 2 individuals with identical AUC C-peptide values had an approximate 5-fold difference in values after adjustments for BMIZ and age. The association between fasting glucose and C-peptide decreased markedly when fasting C-peptide values were adjusted (r = 0.30, P <.01 to r = 0.07, n.s.). Conclusions: C-peptide measures are strongly and independently related to BMIZ and age at and soon after the diagnosis of T1D. Adjustments for BMIZ and age cause substantial changes in C-peptide values, and impact the association between glycemia and C-peptide. Such adjustments can improve assessments of β-cell impairment at diagnosis.

Original languageEnglish (US)
Pages (from-to)403-409
Number of pages7
JournalPediatric Diabetes
Volume19
Issue number3
DOIs
StatePublished - May 1 2018

Fingerprint

C-Peptide
Type 1 Diabetes Mellitus
Body Mass Index
Fasting
Glucose Tolerance Test
Area Under Curve
Meals
Social Adjustment
Linear Models
Glucose

Keywords

  • age
  • body mass index
  • C-peptide
  • children
  • type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1. / Sosenko, Jay M.; Geyer, Susan; Skyler, Jay S.; Rafkin, Lisa E.; Ismail, Heba M.; Libman, Ingrid M.; Liu, Yuk Fun; DiMeglio, Linda; Evans-Molina, Carmella; Palmer, Jerry P.

In: Pediatric Diabetes, Vol. 19, No. 3, 01.05.2018, p. 403-409.

Research output: Contribution to journalArticle

Sosenko, Jay M. ; Geyer, Susan ; Skyler, Jay S. ; Rafkin, Lisa E. ; Ismail, Heba M. ; Libman, Ingrid M. ; Liu, Yuk Fun ; DiMeglio, Linda ; Evans-Molina, Carmella ; Palmer, Jerry P. / The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1. In: Pediatric Diabetes. 2018 ; Vol. 19, No. 3. pp. 403-409.
@article{e27c590228264db69c6e16d022015c92,
title = "The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1",
abstract = "Background/Objective: The extent of influence of BMI and age on C-peptide at the diagnosis of type 1 diabetes (T1D) is unknown. We thus studied the impact of body mass index Z-scores (BMIZ) and age on C-peptide measures at and soon after the diagnosis of T1D. Methods: Data from Diabetes Prevention Trial-Type 1 (DPT-1) participants <18.0 years at diagnosis was analyzed. Analyses examined associations of C-peptide measures with BMIZ and age in 2 cohorts: oral glucose tolerance tests (OGTTs) at diagnosis (n = 99) and mixed meal tolerance tests (MMTTs) <6 months after diagnosis (n = 80). Multivariable linear regression was utilized. Results: Fasting and area under the curve (AUC) C-peptide from OGTTs (n = 99) at diagnosis and MMTTs (n = 80) after diagnosis were positively associated with BMIZ and age (P <.001 for all). Associations persisted when BMIZ and age were included as independent variables in regression models (P <.001 for all). BMIZ and age explained 31{\%}-47{\%} of the variance of C-peptide measures. In an example, 2 individuals with identical AUC C-peptide values had an approximate 5-fold difference in values after adjustments for BMIZ and age. The association between fasting glucose and C-peptide decreased markedly when fasting C-peptide values were adjusted (r = 0.30, P <.01 to r = 0.07, n.s.). Conclusions: C-peptide measures are strongly and independently related to BMIZ and age at and soon after the diagnosis of T1D. Adjustments for BMIZ and age cause substantial changes in C-peptide values, and impact the association between glycemia and C-peptide. Such adjustments can improve assessments of β-cell impairment at diagnosis.",
keywords = "age, body mass index, C-peptide, children, type 1 diabetes",
author = "Sosenko, {Jay M.} and Susan Geyer and Skyler, {Jay S.} and Rafkin, {Lisa E.} and Ismail, {Heba M.} and Libman, {Ingrid M.} and Liu, {Yuk Fun} and Linda DiMeglio and Carmella Evans-Molina and Palmer, {Jerry P.}",
year = "2018",
month = "5",
day = "1",
doi = "10.1111/pedi.12609",
language = "English (US)",
volume = "19",
pages = "403--409",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Blackwell Munksgaard",
number = "3",

}

TY - JOUR

T1 - The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1

AU - Sosenko, Jay M.

AU - Geyer, Susan

AU - Skyler, Jay S.

AU - Rafkin, Lisa E.

AU - Ismail, Heba M.

AU - Libman, Ingrid M.

AU - Liu, Yuk Fun

AU - DiMeglio, Linda

AU - Evans-Molina, Carmella

AU - Palmer, Jerry P.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background/Objective: The extent of influence of BMI and age on C-peptide at the diagnosis of type 1 diabetes (T1D) is unknown. We thus studied the impact of body mass index Z-scores (BMIZ) and age on C-peptide measures at and soon after the diagnosis of T1D. Methods: Data from Diabetes Prevention Trial-Type 1 (DPT-1) participants <18.0 years at diagnosis was analyzed. Analyses examined associations of C-peptide measures with BMIZ and age in 2 cohorts: oral glucose tolerance tests (OGTTs) at diagnosis (n = 99) and mixed meal tolerance tests (MMTTs) <6 months after diagnosis (n = 80). Multivariable linear regression was utilized. Results: Fasting and area under the curve (AUC) C-peptide from OGTTs (n = 99) at diagnosis and MMTTs (n = 80) after diagnosis were positively associated with BMIZ and age (P <.001 for all). Associations persisted when BMIZ and age were included as independent variables in regression models (P <.001 for all). BMIZ and age explained 31%-47% of the variance of C-peptide measures. In an example, 2 individuals with identical AUC C-peptide values had an approximate 5-fold difference in values after adjustments for BMIZ and age. The association between fasting glucose and C-peptide decreased markedly when fasting C-peptide values were adjusted (r = 0.30, P <.01 to r = 0.07, n.s.). Conclusions: C-peptide measures are strongly and independently related to BMIZ and age at and soon after the diagnosis of T1D. Adjustments for BMIZ and age cause substantial changes in C-peptide values, and impact the association between glycemia and C-peptide. Such adjustments can improve assessments of β-cell impairment at diagnosis.

AB - Background/Objective: The extent of influence of BMI and age on C-peptide at the diagnosis of type 1 diabetes (T1D) is unknown. We thus studied the impact of body mass index Z-scores (BMIZ) and age on C-peptide measures at and soon after the diagnosis of T1D. Methods: Data from Diabetes Prevention Trial-Type 1 (DPT-1) participants <18.0 years at diagnosis was analyzed. Analyses examined associations of C-peptide measures with BMIZ and age in 2 cohorts: oral glucose tolerance tests (OGTTs) at diagnosis (n = 99) and mixed meal tolerance tests (MMTTs) <6 months after diagnosis (n = 80). Multivariable linear regression was utilized. Results: Fasting and area under the curve (AUC) C-peptide from OGTTs (n = 99) at diagnosis and MMTTs (n = 80) after diagnosis were positively associated with BMIZ and age (P <.001 for all). Associations persisted when BMIZ and age were included as independent variables in regression models (P <.001 for all). BMIZ and age explained 31%-47% of the variance of C-peptide measures. In an example, 2 individuals with identical AUC C-peptide values had an approximate 5-fold difference in values after adjustments for BMIZ and age. The association between fasting glucose and C-peptide decreased markedly when fasting C-peptide values were adjusted (r = 0.30, P <.01 to r = 0.07, n.s.). Conclusions: C-peptide measures are strongly and independently related to BMIZ and age at and soon after the diagnosis of T1D. Adjustments for BMIZ and age cause substantial changes in C-peptide values, and impact the association between glycemia and C-peptide. Such adjustments can improve assessments of β-cell impairment at diagnosis.

KW - age

KW - body mass index

KW - C-peptide

KW - children

KW - type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85045879928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045879928&partnerID=8YFLogxK

U2 - 10.1111/pedi.12609

DO - 10.1111/pedi.12609

M3 - Article

C2 - 29171129

AN - SCOPUS:85045879928

VL - 19

SP - 403

EP - 409

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

IS - 3

ER -