The influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival: An analysis of the Survival, Epidemiology, and End Results database

Ali M. Saeed, Rebecca Toonkel, Marilyn K. Glassberg, Dao Nguyen, Jennifer J. Hu, Teresa Zimmers, David J. Robbins, Leonidas Koniaris, Brian E. Lally

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

BACKGROUND: Most studies exploring ethnic/racial disparities in nonsmall cell lung cancer (NSCLC) compare black patients with whites. Currently, the effect of Hispanic ethnicity on the overall survival of NSCLC is poorly understood. Therefore, the authors carried out a large-scale, population-based analysis using the Surveillance, Epidemiology, and End Results (SEER) data base to determine the impact of Hispanic ethnicity the survival of patients with NSCLC. METHODS: The authors identified 172,398 adult patients with pathologically confirmed NSCLC from the SEER data base who were diagnosed between 1988 and 2007. A multivariate Cox proportional hazards regression analysis was used to determine the impact of race/ethnicity on overall survival. Pair-wise comparisons were used to determine whether Hispanic ethnicity influenced NSCLC histology or stage at diagnosis. RESULTS: Compared with non-Hispanic white patients, Hispanic white patients had a statistically significant better overall survival (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.83-0.87), and black patients had worse survival (HR, 1.091; 95% CI, 1.072-1.109). Within the bronchioalveolar carcinoma (BAC) subtype, Hispanic-white patients tend to be over represented (8.1% Hispanic whites vs 5.5% non-Hispanic whites vs 3.7% blacks; P

Original languageEnglish (US)
Pages (from-to)4495-4501
Number of pages7
JournalCancer
Volume118
Issue number18
DOIs
StatePublished - Sep 15 2012
Externally publishedYes

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Survival Analysis
Hispanic Americans
Non-Small Cell Lung Carcinoma
Histology
Epidemiology
Databases
Survival
Confidence Intervals
Regression Analysis
Carcinoma
Population

Keywords

  • Hispanic
  • histology
  • lung cancer
  • race

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival : An analysis of the Survival, Epidemiology, and End Results database. / Saeed, Ali M.; Toonkel, Rebecca; Glassberg, Marilyn K.; Nguyen, Dao; Hu, Jennifer J.; Zimmers, Teresa; Robbins, David J.; Koniaris, Leonidas; Lally, Brian E.

In: Cancer, Vol. 118, No. 18, 15.09.2012, p. 4495-4501.

Research output: Contribution to journalArticle

Saeed, Ali M. ; Toonkel, Rebecca ; Glassberg, Marilyn K. ; Nguyen, Dao ; Hu, Jennifer J. ; Zimmers, Teresa ; Robbins, David J. ; Koniaris, Leonidas ; Lally, Brian E. / The influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival : An analysis of the Survival, Epidemiology, and End Results database. In: Cancer. 2012 ; Vol. 118, No. 18. pp. 4495-4501.
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