The intensive care delirium research agenda: a multinational, interprofessional perspective

Pratik P. Pandharipande, E. Wesley Ely, Rakesh C. Arora, Michele C. Balas, Malaz A. Boustani, Gabriel Heras La Calle, Colm Cunningham, John W. Devlin, Julius Elefante, Jin H. Han, Alasdair M. MacLullich, José R. Maldonado, Alessandro Morandi, Dale M. Needham, Valerie J. Page, Louise Rose, Jorge I.F. Salluh, Tarek Sharshar, Yahya Shehabi, Yoanna SkrobikArjen J.C. Slooter, Heidi A.B. Smith

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.

Original languageEnglish (US)
Pages (from-to)1329-1339
Number of pages11
JournalIntensive Care Medicine
Volume43
Issue number9
DOIs
StatePublished - Sep 1 2017

Keywords

  • Cognitive impairment
  • Delirium
  • Research agenda

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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    Pandharipande, P. P., Ely, E. W., Arora, R. C., Balas, M. C., Boustani, M. A., La Calle, G. H., Cunningham, C., Devlin, J. W., Elefante, J., Han, J. H., MacLullich, A. M., Maldonado, J. R., Morandi, A., Needham, D. M., Page, V. J., Rose, L., Salluh, J. I. F., Sharshar, T., Shehabi, Y., ... Smith, H. A. B. (2017). The intensive care delirium research agenda: a multinational, interprofessional perspective. Intensive Care Medicine, 43(9), 1329-1339. https://doi.org/10.1007/s00134-017-4860-7