The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases

Simon Conway, Thomas Doetschman, Mohamad Azhar

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.

Original languageEnglish
Pages (from-to)1509-1524
Number of pages16
JournalTheScientificWorldJournal
Volume11
DOIs
StatePublished - Jul 28 2011

Fingerprint

Heart Valve Diseases
Bone Morphogenetic Proteins
Heart Valves
cardiovascular disease
Transforming Growth Factor beta
ligand
bone
Ligands
protein
Molecules
homeostasis
Homeostasis

Keywords

  • BMP
  • Bone morphogenetic protein
  • Heart development
  • Heart valves
  • Marfan syndrome
  • Periostin
  • TGFβ
  • Transforming growth factor beta

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases. / Conway, Simon; Doetschman, Thomas; Azhar, Mohamad.

In: TheScientificWorldJournal, Vol. 11, 28.07.2011, p. 1509-1524.

Research output: Contribution to journalArticle

@article{d5b43655c9d44ae59122c0254f020eac,
title = "The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases",
abstract = "Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.",
keywords = "BMP, Bone morphogenetic protein, Heart development, Heart valves, Marfan syndrome, Periostin, TGFβ, Transforming growth factor beta",
author = "Simon Conway and Thomas Doetschman and Mohamad Azhar",
year = "2011",
month = "7",
day = "28",
doi = "10.1100/tsw.2011.132",
language = "English",
volume = "11",
pages = "1509--1524",
journal = "The Scientific World Journal",
issn = "2356-6140",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - The inter-relationship of periostin, TGFβ, and BMP in heart valve development and valvular heart diseases

AU - Conway, Simon

AU - Doetschman, Thomas

AU - Azhar, Mohamad

PY - 2011/7/28

Y1 - 2011/7/28

N2 - Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.

AB - Recent studies have suggested an important role for periostin and transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGFβ and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGFβ and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.

KW - BMP

KW - Bone morphogenetic protein

KW - Heart development

KW - Heart valves

KW - Marfan syndrome

KW - Periostin

KW - TGFβ

KW - Transforming growth factor beta

UR - http://www.scopus.com/inward/record.url?scp=84860390603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860390603&partnerID=8YFLogxK

U2 - 10.1100/tsw.2011.132

DO - 10.1100/tsw.2011.132

M3 - Article

VL - 11

SP - 1509

EP - 1524

JO - The Scientific World Journal

JF - The Scientific World Journal

SN - 2356-6140

ER -