The international testicular cancer linkage consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

Phuong L. Mai, Michael Friedlander, Kathy Tucker, Kelly Anne Phillips, David Hogg, Michael A.S. Jewett, Radka Lohynska, Gedske Daugaard, Stéphane Richard, Catherine Bonaïti-Pellié, Axel Heidenreich, Peter Albers, Istvan Bodrogi, Lajos Geczi, Edith Olah, Peter A. Daly, Parry Guilford, Sophie D. Fosså, Ketil Heimdal, Ludmila LiubchenkoSergei A. Tjulandin, Hans Stoll, Walter Weber, Douglas F. Easton, Darshna Dudakia, Robert Huddart, Michael R. Stratton, Lawrence Einhorn, Larissa Korde, Katherine L. Nathanson, D. Timothy Bishop, Elizabeth A. Rapley, Mark H. Greene

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with ≥2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism, TGCT was more likely to occur in the ipsilateral testis (κ = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families. Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial cases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation.

Original languageEnglish (US)
Pages (from-to)492-499
Number of pages8
JournalUrologic Oncology: Seminars and Original Investigations
Volume28
Issue number5
DOIs
StatePublished - Sep 2010

Keywords

  • Clinicopathologic characteristics
  • Epidemiology
  • Familial
  • Testicular neoplasms

ASJC Scopus subject areas

  • Oncology
  • Urology

Fingerprint Dive into the research topics of 'The international testicular cancer linkage consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred'. Together they form a unique fingerprint.

  • Cite this

    Mai, P. L., Friedlander, M., Tucker, K., Phillips, K. A., Hogg, D., Jewett, M. A. S., Lohynska, R., Daugaard, G., Richard, S., Bonaïti-Pellié, C., Heidenreich, A., Albers, P., Bodrogi, I., Geczi, L., Olah, E., Daly, P. A., Guilford, P., Fosså, S. D., Heimdal, K., ... Greene, M. H. (2010). The international testicular cancer linkage consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. Urologic Oncology: Seminars and Original Investigations, 28(5), 492-499. https://doi.org/10.1016/j.urolonc.2008.10.004