The international testicular cancer linkage consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

Phuong L. Mai, Michael Friedlander, Kathy Tucker, Kelly Anne Phillips, David Hogg, Michael A S Jewett, Radka Lohynska, Gedske Daugaard, Stéphane Richard, Catherine Bonaïti-Pellié, Axel Heidenreich, Peter Albers, Istvan Bodrogi, Lajos Geczi, Edith Olah, Peter A. Daly, Parry Guilford, Sophie D. Fosså, Ketil Heimdal, Ludmila LiubchenkoSergei A. Tjulandin, Hans Stoll, Walter Weber, Douglas F. Easton, Darshna Dudakia, Robert Huddart, Michael R. Stratton, Lawrence Einhorn, Larissa Korde, Katherine L. Nathanson, D. Timothy Bishop, Elizabeth A. Rapley, Mark H. Greene

Research output: Contribution to journalArticle

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Abstract

Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with ≥2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism, TGCT was more likely to occur in the ipsilateral testis (κ = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families. Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial cases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation.

Original languageEnglish
Pages (from-to)492-499
Number of pages8
JournalUrologic Oncology: Seminars and Original Investigations
Volume28
Issue number5
DOIs
StatePublished - Sep 2010

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Testicular Neoplasms
Cryptorchidism
Seminoma
Testicular Germ Cell Tumor
Testis
Population

Keywords

  • Clinicopathologic characteristics
  • Epidemiology
  • Familial
  • Testicular neoplasms

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

The international testicular cancer linkage consortium : A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. / Mai, Phuong L.; Friedlander, Michael; Tucker, Kathy; Phillips, Kelly Anne; Hogg, David; Jewett, Michael A S; Lohynska, Radka; Daugaard, Gedske; Richard, Stéphane; Bonaïti-Pellié, Catherine; Heidenreich, Axel; Albers, Peter; Bodrogi, Istvan; Geczi, Lajos; Olah, Edith; Daly, Peter A.; Guilford, Parry; Fosså, Sophie D.; Heimdal, Ketil; Liubchenko, Ludmila; Tjulandin, Sergei A.; Stoll, Hans; Weber, Walter; Easton, Douglas F.; Dudakia, Darshna; Huddart, Robert; Stratton, Michael R.; Einhorn, Lawrence; Korde, Larissa; Nathanson, Katherine L.; Bishop, D. Timothy; Rapley, Elizabeth A.; Greene, Mark H.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 28, No. 5, 09.2010, p. 492-499.

Research output: Contribution to journalArticle

Mai, PL, Friedlander, M, Tucker, K, Phillips, KA, Hogg, D, Jewett, MAS, Lohynska, R, Daugaard, G, Richard, S, Bonaïti-Pellié, C, Heidenreich, A, Albers, P, Bodrogi, I, Geczi, L, Olah, E, Daly, PA, Guilford, P, Fosså, SD, Heimdal, K, Liubchenko, L, Tjulandin, SA, Stoll, H, Weber, W, Easton, DF, Dudakia, D, Huddart, R, Stratton, MR, Einhorn, L, Korde, L, Nathanson, KL, Bishop, DT, Rapley, EA & Greene, MH 2010, 'The international testicular cancer linkage consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred', Urologic Oncology: Seminars and Original Investigations, vol. 28, no. 5, pp. 492-499. https://doi.org/10.1016/j.urolonc.2008.10.004
Mai, Phuong L. ; Friedlander, Michael ; Tucker, Kathy ; Phillips, Kelly Anne ; Hogg, David ; Jewett, Michael A S ; Lohynska, Radka ; Daugaard, Gedske ; Richard, Stéphane ; Bonaïti-Pellié, Catherine ; Heidenreich, Axel ; Albers, Peter ; Bodrogi, Istvan ; Geczi, Lajos ; Olah, Edith ; Daly, Peter A. ; Guilford, Parry ; Fosså, Sophie D. ; Heimdal, Ketil ; Liubchenko, Ludmila ; Tjulandin, Sergei A. ; Stoll, Hans ; Weber, Walter ; Easton, Douglas F. ; Dudakia, Darshna ; Huddart, Robert ; Stratton, Michael R. ; Einhorn, Lawrence ; Korde, Larissa ; Nathanson, Katherine L. ; Bishop, D. Timothy ; Rapley, Elizabeth A. ; Greene, Mark H. / The international testicular cancer linkage consortium : A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred. In: Urologic Oncology: Seminars and Original Investigations. 2010 ; Vol. 28, No. 5. pp. 492-499.
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AU - Mai, Phuong L.

AU - Friedlander, Michael

AU - Tucker, Kathy

AU - Phillips, Kelly Anne

AU - Hogg, David

AU - Jewett, Michael A S

AU - Lohynska, Radka

AU - Daugaard, Gedske

AU - Richard, Stéphane

AU - Bonaïti-Pellié, Catherine

AU - Heidenreich, Axel

AU - Albers, Peter

AU - Bodrogi, Istvan

AU - Geczi, Lajos

AU - Olah, Edith

AU - Daly, Peter A.

AU - Guilford, Parry

AU - Fosså, Sophie D.

AU - Heimdal, Ketil

AU - Liubchenko, Ludmila

AU - Tjulandin, Sergei A.

AU - Stoll, Hans

AU - Weber, Walter

AU - Easton, Douglas F.

AU - Dudakia, Darshna

AU - Huddart, Robert

AU - Stratton, Michael R.

AU - Einhorn, Lawrence

AU - Korde, Larissa

AU - Nathanson, Katherine L.

AU - Bishop, D. Timothy

AU - Rapley, Elizabeth A.

AU - Greene, Mark H.

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