The inverse relationship between the microstructural variability of amygdala-prefrontal pathways and trait anxiety is moderated by sex

M. Justin Kim, Annemarie C. Brown, Alison M. Mattek, Samantha J. Chavez, James M. Taylor, Amy L. Palmer, Yu-Chien Wu, Paul J. Whalen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Anxiety impacts the quality of everyday life and may facilitate the development of affective disorders,possibly through concurrent alterations in neural circuitry. Findings from multimodal neuroimaging studies suggest that trait-anxious individuals may have a reduced capacity for efficient communication between the amygdala and the ventral prefrontal cortex (vPFC). A diffusion-weighted imaging protocol with 61 directions was used to identify lateral and medial amygdala-vPFC white matter pathways. The structural integrity of both pathways was inversely correlated with self-reported levels of trait anxiety. When this mask from our first dataset was then applied to an independent validation dataset,both pathways again showed a consistent inverse relationship with trait anxiety. Importantly,a moderating effect of sex was found,demonstrating that the observed brain-anxiety relationship was stronger in females. These data reveal a potential neuroanatomical mediator of previously documented functional alterations in amygdala-prefrontal connectivity that is associated with trait anxiety,which might prove informative for future studies of psychopathology.

Original languageEnglish (US)
Article number93
JournalFrontiers in Systems Neuroscience
Volume10
Issue numberNOV
DOIs
StatePublished - Nov 16 2016

Fingerprint

Amygdala
Anxiety
Prefrontal Cortex
Masks
Psychopathology
Mood Disorders
Neuroimaging
Communication
Quality of Life
Brain
Datasets

Keywords

  • Amygdala
  • Anxiety
  • Connectivity
  • Ventral prefrontal cortex
  • White matter

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

The inverse relationship between the microstructural variability of amygdala-prefrontal pathways and trait anxiety is moderated by sex. / Kim, M. Justin; Brown, Annemarie C.; Mattek, Alison M.; Chavez, Samantha J.; Taylor, James M.; Palmer, Amy L.; Wu, Yu-Chien; Whalen, Paul J.

In: Frontiers in Systems Neuroscience, Vol. 10, No. NOV, 93, 16.11.2016.

Research output: Contribution to journalArticle

Kim, M. Justin ; Brown, Annemarie C. ; Mattek, Alison M. ; Chavez, Samantha J. ; Taylor, James M. ; Palmer, Amy L. ; Wu, Yu-Chien ; Whalen, Paul J. / The inverse relationship between the microstructural variability of amygdala-prefrontal pathways and trait anxiety is moderated by sex. In: Frontiers in Systems Neuroscience. 2016 ; Vol. 10, No. NOV.
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