The involvement of subchondral mineralized tissues in osteoarthrosis

Quantitative microscopic evidence

David Burr, Mitchell B. Schaffler

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

This paper reviews evidence for the role of subchondral bone and calcified cartilage in the initiation and progression of osteoarthrosis (OA). There is consensus that OA is characterized by subchondral sclerosis, but disagreement about whether bone changes are concurrent with, primary to, or secondary to cartilage deterioration. Clinical observation suggests that bone density and cartilage fibrillation are inversely related. Evidence from the rabbit impulsive loading model is consistent with early bone changes, but evidence from other models of subchondral stiffening, such as the sheep metallic implant model, do not strongly support this idea. However, evidence from tibial angulation models and from the Pond-Nuki (anterior cruciate ligament resection) model show evidence that bone changes precede cartilage fibrillation temporally, and are associated spatially within a single joint. Evidence is also presented for the importance of calcified cartilage changes in pre-disposing the joint towards progression to OA. Microdamage accumulation and repair by vascular invasion may be a component of the pathogenesis of OA in some cases, but more work is needed to demonstrate this conclusively. We conclude that changes in the subchondral mineralized tissues are not required for initiation of cartilage fibrillation, but may be necessary for progression, and that only changes in bone and calcified cartilage close to the joint are significant to the disease process.

Original languageEnglish
Pages (from-to)343-357
Number of pages15
JournalMicroscopy Research and Technique
Volume37
Issue number4
DOIs
StatePublished - May 15 1997

Fingerprint

cartilage
osteoarthritis
Cartilage
Osteoarthritis
Bone
Tissue
bones
fibrillation
Bone and Bones
joints (animal)
progressions
Joints
anterior cruciate ligament
bone mineral content
sheep
pathogenesis
ligaments
stiffening
Anterior Cruciate Ligament
Ligaments

Keywords

  • Arthritis
  • Articular
  • Biomechanics
  • Cartilage
  • Histomorphometry
  • Joints
  • Subchondral bone

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

The involvement of subchondral mineralized tissues in osteoarthrosis : Quantitative microscopic evidence. / Burr, David; Schaffler, Mitchell B.

In: Microscopy Research and Technique, Vol. 37, No. 4, 15.05.1997, p. 343-357.

Research output: Contribution to journalArticle

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