The keratinocyte as a target for staphylococcal bacterial toxins

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Skin infections with Staphylococcus aureus are not only an important cause of morbidity and even mortality, but are thought to serve as initiation and/or persistance factors for numerous inflammatory skin diseases, including psoriasis and atopic dermatitis. One mechanism by which S. aureus can modulate the immune system is through the production of proteins such as superantigenic toxins, Protein A, as well through the cytolytic α-toxin. This review serves to discuss the biology of these three types of proteins, with emphasis on their ability to stimulate the production of powerful pro-inflammatory lipid-and protein-derived cytokines in keratinocytes. Characterization of interactions between these proteins and the keratinocyte can provide a better understanding of how bacterial infection modulates inflammatory skin diseases, as well as provide the basis for improved therapies involving antibacterial agents.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalJournal of Investigative Dermatology Symposium Proceedings
Volume6
Issue number3
StatePublished - 2001

Fingerprint

Bacterial Toxins
Keratinocytes
Skin Diseases
Staphylococcus aureus
Proteins
Staphylococcal Protein A
Atopic Dermatitis
Psoriasis
Bacterial Infections
Immune System
Cytokines
Anti-Bacterial Agents
Morbidity
Lipids
Skin
Mortality
Infection

Keywords

  • α-toxin
  • Keratinocytes
  • Platelet-activating factor
  • Protein a
  • Staphylococcus aureus
  • Superantigens

ASJC Scopus subject areas

  • Dermatology

Cite this

The keratinocyte as a target for staphylococcal bacterial toxins. / Travers, Jeffrey.

In: Journal of Investigative Dermatology Symposium Proceedings, Vol. 6, No. 3, 2001, p. 225-230.

Research output: Contribution to journalArticle

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