Kinesins are enzymes that use the energy of ATP hydrolysis to generate force and/or motility along microtubule polymers. A large number of kinesin enzymes are involved in mitosis with important roles in spindle assembly, chromosome congression, chromosome segregation, and cytokinesis. In this chapter, we begin with a description of the kinesin motor domain and the general principles of chemomechanical coupling. We then discuss general principles of kinesin organization and regulation. Finally, we provide a brief description of the kinesins that are known to function in mitosis, which will be the focus of the later chapters of this book.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)