The kinesin superfamily

Kristen J. Verhey, Jared C. Cochran, Claire Walczak

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Kinesins are enzymes that use the energy of ATP hydrolysis to generate force and/or motility along microtubule polymers. A large number of kinesin enzymes are involved in mitosis with important roles in spindle assembly, chromosome congression, chromosome segregation, and cytokinesis. In this chapter, we begin with a description of the kinesin motor domain and the general principles of chemomechanical coupling. We then discuss general principles of kinesin organization and regulation. Finally, we provide a brief description of the kinesins that are known to function in mitosis, which will be the focus of the later chapters of this book.

Original languageEnglish (US)
Title of host publicationKinesins and Cancer
PublisherSense Publishers
Pages1-26
Number of pages26
ISBN (Print)9789401797320, 9789401797313
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

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