The kinetics of copper-62-PTSM in the normal human heart

R. S.B. Beanlands, O. Muzik, M. Mintun, T. Mangner, K. Lee, N. Petry, G. D. Hutchins, M. Schwaiger

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39 Scopus citations

Abstract

Copper-62-labeled pyruvaldehyde bis(N-4-methylthiosemicarbazone) copper(II) (PTSM) is a generator-produced myocardial perfusion tracer. Animal studies have shown high myocardial tissue extraction and prolonged retention. The aim of this study was to define myocardial kinetics of 62Cu-PTSM and to determine its suitability for evaluating myocardial perfusion at rest and during pharmacological vasodilation in human subjects. In six healthy volunteers, 62Cu-PTSM was administered at baseline and during a 6-min adenosine infusion (140 μg/kg/min). Dynamic PET imaging with high temporal resolution was performed over 20 min. Good image quality was observed at rest and following adenosine. Myocardial kinetics demonstrated prolonged tissue retention with a clearance half-life of 105 ± 49 min at rest and 101 ± 65 min following adenosine (p = ns). Copper-62-PTSM tissue retention was quantified and showed only a 1.97-fold increase from rest to adenosine studies. This suggests attenuation of tracer retention at high flow rates. Copper-62-PTSM represents a promising new radiopharmaceutical for the evaluation of myocardial perfusion in the human heart.

Original languageEnglish (US)
Pages (from-to)684-690
Number of pages7
JournalJournal of Nuclear Medicine
Volume33
Issue number5
StatePublished - 1992

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Beanlands, R. S. B., Muzik, O., Mintun, M., Mangner, T., Lee, K., Petry, N., Hutchins, G. D., & Schwaiger, M. (1992). The kinetics of copper-62-PTSM in the normal human heart. Journal of Nuclear Medicine, 33(5), 684-690.