The kit receptor and its ligand, steel factor, as regulators of hemopoiesis

Hal Broxmeyer, R. Maze, K. Miyazawa, C. Carow, P. C. Hendrie, S. Cooper, G. Hangoc, S. Vadhan-Raj, L. Lu

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Mouse strains carrying mutations at the Dominant White Spotting (W) locus or the Steel (SL) locus are anemic and display defects in pigmentation and gametogenesis. In W mutants the anemia is due to a deficiency of hemopoietic stem cells and, in SL mutants, to a deficiency of supporting stromal cells in the bone marrow. The W locus encodes the c-kit proto-oncogene product, a cell surface receptor with protein-tyrosine kinase activity, and the SL locus encodes its ligand, a hemopoietic cytokine known variously as Steel factor (SLF), mast cell growth factor, stem cell factor, and Kit ligand. SLF can synergize with a number of other cytokines to stimulate growth of hemopoietic progenitors in vitro and stimulates blood cells production in vivo in animals. Here we review the biological activities of SLF, with particular emphasis on its effects on hemopoietic stem and progenitor cells. We also discuss present knowledge of the molecules involved in SLF-triggered signal transduction, and speculate on potential therapeutic applications for SLF in human disease.

Original languageEnglish
Pages (from-to)480-487
Number of pages8
JournalCancer Cells
Volume3
Issue number12
StatePublished - 1991

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Stem Cell Factor
Ligands
Steel
Stem Cells
Cytokines
Gametogenesis
Metrorrhagia
Proto-Oncogenes
Oncogene Proteins
Pigmentation
Receptor Protein-Tyrosine Kinases
Cell Surface Receptors
Mesenchymal Stromal Cells
Anemia
Signal Transduction
Blood Cells
Mutation
Growth

ASJC Scopus subject areas

  • Cancer Research

Cite this

Broxmeyer, H., Maze, R., Miyazawa, K., Carow, C., Hendrie, P. C., Cooper, S., ... Lu, L. (1991). The kit receptor and its ligand, steel factor, as regulators of hemopoiesis. Cancer Cells, 3(12), 480-487.

The kit receptor and its ligand, steel factor, as regulators of hemopoiesis. / Broxmeyer, Hal; Maze, R.; Miyazawa, K.; Carow, C.; Hendrie, P. C.; Cooper, S.; Hangoc, G.; Vadhan-Raj, S.; Lu, L.

In: Cancer Cells, Vol. 3, No. 12, 1991, p. 480-487.

Research output: Contribution to journalArticle

Broxmeyer, H, Maze, R, Miyazawa, K, Carow, C, Hendrie, PC, Cooper, S, Hangoc, G, Vadhan-Raj, S & Lu, L 1991, 'The kit receptor and its ligand, steel factor, as regulators of hemopoiesis', Cancer Cells, vol. 3, no. 12, pp. 480-487.
Broxmeyer H, Maze R, Miyazawa K, Carow C, Hendrie PC, Cooper S et al. The kit receptor and its ligand, steel factor, as regulators of hemopoiesis. Cancer Cells. 1991;3(12):480-487.
Broxmeyer, Hal ; Maze, R. ; Miyazawa, K. ; Carow, C. ; Hendrie, P. C. ; Cooper, S. ; Hangoc, G. ; Vadhan-Raj, S. ; Lu, L. / The kit receptor and its ligand, steel factor, as regulators of hemopoiesis. In: Cancer Cells. 1991 ; Vol. 3, No. 12. pp. 480-487.
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