The lack of effect of chronic metabolic acidosis on 25 OH vitamin D metabolism and serum parathyroid hormone in humans

H. P. Weber, R. W. Gray, Jesus Dominguez, J. Lemann

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The authors evaluated the turnover of the plasma 25 OH vitamin D pool, acid, and mineral balances in paired balance studies of 6 normal subjects during normal acid base conditions and during stable chronic metabolic acidosis induced by NH4Cl. Positive acid balances and negative Ca balances due to hypercalciuria were observed as previously reported. Plasma 25 OH D pool turnover averaged 6.1 ± 0.4 nmol/day during control and did not change during acidosis (6.5 ± 0.5 nmol/day) nor were any significant increments in net intestinal absorption of Ca, PO4, or Mg, the physiological expression of vitamin D action, observed during acidosis. In 3 other subjects, repetitive measurements of serum iPTH during 7 control days and 24 days of stable NH4Cl acidosis showed no changes. The authors interpret the data to support the hypothesis that neither PTH nor vitamin D and its metabolites mediates the increase in net bone resorption that must accompany chronic metabolic acidosis.

Original languageEnglish (US)
Pages (from-to)1047-1055
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume43
Issue number5
StatePublished - 1976
Externally publishedYes

Fingerprint

Acidosis
Parathyroid Hormone
Metabolism
Vitamin D
Acids
Serum
Plasmas
Metabolites
Minerals
Bone
Hypercalciuria
Intestinal Absorption
Bone Resorption
human PTH protein

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The lack of effect of chronic metabolic acidosis on 25 OH vitamin D metabolism and serum parathyroid hormone in humans. / Weber, H. P.; Gray, R. W.; Dominguez, Jesus; Lemann, J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 43, No. 5, 1976, p. 1047-1055.

Research output: Contribution to journalArticle

@article{d10e15dd3a054b3aab2c6aaf4f101e79,
title = "The lack of effect of chronic metabolic acidosis on 25 OH vitamin D metabolism and serum parathyroid hormone in humans",
abstract = "The authors evaluated the turnover of the plasma 25 OH vitamin D pool, acid, and mineral balances in paired balance studies of 6 normal subjects during normal acid base conditions and during stable chronic metabolic acidosis induced by NH4Cl. Positive acid balances and negative Ca balances due to hypercalciuria were observed as previously reported. Plasma 25 OH D pool turnover averaged 6.1 ± 0.4 nmol/day during control and did not change during acidosis (6.5 ± 0.5 nmol/day) nor were any significant increments in net intestinal absorption of Ca, PO4, or Mg, the physiological expression of vitamin D action, observed during acidosis. In 3 other subjects, repetitive measurements of serum iPTH during 7 control days and 24 days of stable NH4Cl acidosis showed no changes. The authors interpret the data to support the hypothesis that neither PTH nor vitamin D and its metabolites mediates the increase in net bone resorption that must accompany chronic metabolic acidosis.",
author = "Weber, {H. P.} and Gray, {R. W.} and Jesus Dominguez and J. Lemann",
year = "1976",
language = "English (US)",
volume = "43",
pages = "1047--1055",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "5",

}

TY - JOUR

T1 - The lack of effect of chronic metabolic acidosis on 25 OH vitamin D metabolism and serum parathyroid hormone in humans

AU - Weber, H. P.

AU - Gray, R. W.

AU - Dominguez, Jesus

AU - Lemann, J.

PY - 1976

Y1 - 1976

N2 - The authors evaluated the turnover of the plasma 25 OH vitamin D pool, acid, and mineral balances in paired balance studies of 6 normal subjects during normal acid base conditions and during stable chronic metabolic acidosis induced by NH4Cl. Positive acid balances and negative Ca balances due to hypercalciuria were observed as previously reported. Plasma 25 OH D pool turnover averaged 6.1 ± 0.4 nmol/day during control and did not change during acidosis (6.5 ± 0.5 nmol/day) nor were any significant increments in net intestinal absorption of Ca, PO4, or Mg, the physiological expression of vitamin D action, observed during acidosis. In 3 other subjects, repetitive measurements of serum iPTH during 7 control days and 24 days of stable NH4Cl acidosis showed no changes. The authors interpret the data to support the hypothesis that neither PTH nor vitamin D and its metabolites mediates the increase in net bone resorption that must accompany chronic metabolic acidosis.

AB - The authors evaluated the turnover of the plasma 25 OH vitamin D pool, acid, and mineral balances in paired balance studies of 6 normal subjects during normal acid base conditions and during stable chronic metabolic acidosis induced by NH4Cl. Positive acid balances and negative Ca balances due to hypercalciuria were observed as previously reported. Plasma 25 OH D pool turnover averaged 6.1 ± 0.4 nmol/day during control and did not change during acidosis (6.5 ± 0.5 nmol/day) nor were any significant increments in net intestinal absorption of Ca, PO4, or Mg, the physiological expression of vitamin D action, observed during acidosis. In 3 other subjects, repetitive measurements of serum iPTH during 7 control days and 24 days of stable NH4Cl acidosis showed no changes. The authors interpret the data to support the hypothesis that neither PTH nor vitamin D and its metabolites mediates the increase in net bone resorption that must accompany chronic metabolic acidosis.

UR - http://www.scopus.com/inward/record.url?scp=0017142291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017142291&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 1047

EP - 1055

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -