The landscape of EGFR pathways and personalized management of non-small-cell lung cancer

Liang Cheng, Shaobo Zhang, Riley Alexander, Yongxue Yao, Gregory T. MacLennan, Chong Xian Pan, Jiaoti Huang, Mingsheng Wang, Rodolfo Montironi, Antonio Lopez-Beltran

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Two classes of anti-EGF receptor (EGFR) agents, monoclonal anti-EGFR antibodies and small-molecule EGFR tyrosine kinase inhibitors, have been used for the treatment of non-small-cell lung cancer (NSCLC). However, only a subset of patients will benefit from EGFR-targeted therapy. The discovery of biomarkers that select the appropriate patients for the therapy and predict the responses to the therapy is urgently needed. Molecular genetic analyses provide new insights into EGFR pathway alterations and demonstrate promise for predicting the clinical outcome of patients with NSCLC. In this article, we summarize the latest available knowledge on the clinical impact of EGFR mutations, gene copy number, EGFR overexpression, phosphorylation expression and the alteration of the EGFR pathway downstream factors in predicting the response to EGFR-targeted therapy in NSCLC patients. The role of KRAS and BRAF mutations and ALK rearrangement in lung cancer-targeted therapy, are also reviewed.

Original languageEnglish (US)
Pages (from-to)519-541
Number of pages23
JournalFuture Oncology
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2011

Keywords

  • EGF receptor
  • EML4-ALK
  • FISH
  • lung cancer
  • molecular genetic pathology
  • non-small-cell lung cancer
  • personalized medicine
  • targeted therapy
  • tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Cheng, L., Zhang, S., Alexander, R., Yao, Y., MacLennan, G. T., Pan, C. X., Huang, J., Wang, M., Montironi, R., & Lopez-Beltran, A. (2011). The landscape of EGFR pathways and personalized management of non-small-cell lung cancer. Future Oncology, 7(4), 519-541. https://doi.org/10.2217/fon.11.25