A retrospective study of the comparative effects of vitamin D, dihydrotachysterol and lα‐hydroxy vitamin D3 was undertaken in twentyeight patients with hypo‐parathyroidism. The vitamin D compounds restored plasma calcium to the normal range in most patients with comparable actions on the gut, bone and Kidney. Although the vitamin D compounds had a direct action on kidney and bone in the absence of PTH, the major action in maintaining plasma calcium was on the gut. Plasma phosphate fell due to a reduction in renal tubular reabsorption. Dihydrotachysterol and lα‐hydroxyvitamin D3 had significant practical advantages over vitamin D in their rapid onset of action and their relatively short biological half–life.
|Original language||English (US)|
|State||Published - Dec 1977|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism