THE MANAGEMENT OF H Y POP A R ATH YRO ID ISM WITH lα‐HYDROXYVITAMIN D3

P. J. HEYBURN, M. PEACOCK

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A retrospective study of the comparative effects of vitamin D, dihydrotachysterol and lα‐hydroxy vitamin D3 was undertaken in twentyeight patients with hypo‐parathyroidism. The vitamin D compounds restored plasma calcium to the normal range in most patients with comparable actions on the gut, bone and Kidney. Although the vitamin D compounds had a direct action on kidney and bone in the absence of PTH, the major action in maintaining plasma calcium was on the gut. Plasma phosphate fell due to a reduction in renal tubular reabsorption. Dihydrotachysterol and lα‐hydroxyvitamin D3 had significant practical advantages over vitamin D in their rapid onset of action and their relatively short biological half–life.

Original languageEnglish (US)
Pages (from-to)209s-214s
JournalClinical Endocrinology
Volume7
DOIs
StatePublished - Dec 1977

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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