The Many Faces of Long Noncoding RNAs in Cancer

Xue Wu, Oana M. Tudoran, George A. Calin, Mircea Ivan

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Significance: The emerging connections between an increasing number of long noncoding RNAs (lncRNAs) and oncogenic hallmarks provide a new twist to tumor complexity. Recent Advances: In the present review, we highlight specific lncRNAs that have been studied in relation to tumorigenesis, either as participants in the neoplastic process or as markers of pathway activity or drug response. These transcripts are typically deregulated by oncogenic or tumor-suppressing signals or respond to microenvironmental conditions such as hypoxia. Critical Issues: Among these transcripts are lncRNAs sufficiently divergent between mouse and human genomes that may contribute to biological differences between species. Future Directions: From a translational standpoint, knowledge about primate-specific lncRNAs may help explain the reason behind the failure to reproduce the results from mouse cancer models in human cell-based systems. Antioxid. Redox Signal. 29, 922-935.

Original languageEnglish (US)
Pages (from-to)922-935
Number of pages14
JournalAntioxidants and Redox Signaling
Volume29
Issue number9
DOIs
StatePublished - Sep 20 2018

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Keywords

  • cancer
  • hypoxia
  • metabolism
  • microenvironment
  • non-coding RNA

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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