The mayo classification system for traumatic brain injury severity

James F. Malec, Allen W. Brown, Cynthia L. Leibson, Julie Testa Flaada, Jayawant N. Mandrekar, Nancy N. Diehl, Patricia K. Perkins

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Purpose: To develop a single TBI severity classification system based on commonly used TBI severity measures and indicators that (1) maximally uses available positive evidence to classify TBI severity in three categories: (a) Moderate-Severe (Definite) TBI, (b) Mild (Probable) TBI, (c) Symptomatic (Possible) TBI; (2) reflects current clinical knowledge and relevance; and (3) classifies a larger number of cases than single indicator systems with reasonable accuracy. Main Findings: The study sample of a defined population consisted of 1501 unique Olmsted County residents with at least one confirmed TBI event from 1985 to 1999. Within the sample, 1678 TBI events were confirmed. Single measures of TBI severity were not available in a large percentage of these events, i.e., Glasgow Coma Scale (GCS) was absent in 1242 (74.0%); loss of consciousness, absent in 178 (70.2%), posttraumatic amnesia (PTA), absent in 974 (58.1%), head CT, not done in 827 (49.3%). The Mayo Classification System for TBI Severity was developed to classify cases based on available indicators that included death due to TBI, trauma-related neuroimaging abnormalities, GCS, PTA, loss of consciousness and specified post-concussive symptoms. Using the Mayo system, all cases were classified. For the Moderate-Severe (Definite) TBI classification, estimated sensitivity was 89% and estimated specificity was 98%. Conclusions: By maximally using relevant available positive evidence, the Mayo system classifies a larger number of cases than single indicator systems with reasonable accuracy. This system may be of use in retrospective research and for determination of TBI severity for planning postacute clinical care.

Original languageEnglish (US)
Pages (from-to)1417-1424
Number of pages8
JournalJournal of Neurotrauma
Volume24
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

Fingerprint

Glasgow Coma Scale
Amnesia
Unconsciousness
Subacute Care
Post-Concussion Syndrome
Neuroimaging
Head
Wounds and Injuries
Research
Population
Traumatic Brain Injury

Keywords

  • Brain injury
  • Classification

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Malec, J. F., Brown, A. W., Leibson, C. L., Flaada, J. T., Mandrekar, J. N., Diehl, N. N., & Perkins, P. K. (2007). The mayo classification system for traumatic brain injury severity. Journal of Neurotrauma, 24(9), 1417-1424. https://doi.org/10.1089/neu.2006.0245

The mayo classification system for traumatic brain injury severity. / Malec, James F.; Brown, Allen W.; Leibson, Cynthia L.; Flaada, Julie Testa; Mandrekar, Jayawant N.; Diehl, Nancy N.; Perkins, Patricia K.

In: Journal of Neurotrauma, Vol. 24, No. 9, 09.2007, p. 1417-1424.

Research output: Contribution to journalArticle

Malec, JF, Brown, AW, Leibson, CL, Flaada, JT, Mandrekar, JN, Diehl, NN & Perkins, PK 2007, 'The mayo classification system for traumatic brain injury severity', Journal of Neurotrauma, vol. 24, no. 9, pp. 1417-1424. https://doi.org/10.1089/neu.2006.0245
Malec JF, Brown AW, Leibson CL, Flaada JT, Mandrekar JN, Diehl NN et al. The mayo classification system for traumatic brain injury severity. Journal of Neurotrauma. 2007 Sep;24(9):1417-1424. https://doi.org/10.1089/neu.2006.0245
Malec, James F. ; Brown, Allen W. ; Leibson, Cynthia L. ; Flaada, Julie Testa ; Mandrekar, Jayawant N. ; Diehl, Nancy N. ; Perkins, Patricia K. / The mayo classification system for traumatic brain injury severity. In: Journal of Neurotrauma. 2007 ; Vol. 24, No. 9. pp. 1417-1424.
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