The mechanism of calcium-dependent activation of respiration of liver mitochondria from hibernating ground squirrels, Citellus undulatus

N. N. Brustovetsky, M. V. Egorova, D. Yu Gnutov

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Abstract

1. 1. It is shown that Ca2+-dependent activation of respiration of liver mitochondria from hibernating ground squirrels is accompanied by mitochondrial swelling. 2. 2. The swelling of mitochondria from hibernating ground squirrels, as well as the activation of mitochondrial respiration, is precluded by cyclosporin A, p-bromphenacylbromide and oligomycin. Carboxyatractiloside, on the contrary, under these conditions favors the swelling and the acceleration of respiration. 3. 3. It was concluded that Ca2+-dependent activation of hibernating ground squirrel liver mitochondrial respiration resulted from the appearance of a non-specific permeability pathway and from swelling of mitochondria.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume106
Issue number2
DOIs
StatePublished - Oct 1993

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ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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