The mechanism of V(D)J recombination: Site-specificity, reaction fidelity and immunologic diversity

Michael R. Lieber, Ching-Pin Chang, Michael Gallo, George Gauss, Rachel Gerstein, Angel Islas

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Site-specific recombination reactions in higher eukaryotes are uncommon, perhaps because of the potential genomic instability that they may create. We focus this review on the issues of site-specificity, reaction fidelity and immunologic diversity in the V(D)J recombination reaction.

Original languageEnglish (US)
Pages (from-to)143-153
Number of pages11
JournalSeminars in Immunology
Volume6
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

V(D)J Recombination
Genomic Instability
Eukaryota
Genetic Recombination

Keywords

  • Accessibility
  • Antigen receptor genes
  • Gene rearrangement
  • Genome stability
  • Recombination

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Lieber, M. R., Chang, C-P., Gallo, M., Gauss, G., Gerstein, R., & Islas, A. (1994). The mechanism of V(D)J recombination: Site-specificity, reaction fidelity and immunologic diversity. Seminars in Immunology, 6(3), 143-153.

The mechanism of V(D)J recombination : Site-specificity, reaction fidelity and immunologic diversity. / Lieber, Michael R.; Chang, Ching-Pin; Gallo, Michael; Gauss, George; Gerstein, Rachel; Islas, Angel.

In: Seminars in Immunology, Vol. 6, No. 3, 1994, p. 143-153.

Research output: Contribution to journalArticle

Lieber, MR, Chang, C-P, Gallo, M, Gauss, G, Gerstein, R & Islas, A 1994, 'The mechanism of V(D)J recombination: Site-specificity, reaction fidelity and immunologic diversity', Seminars in Immunology, vol. 6, no. 3, pp. 143-153.
Lieber MR, Chang C-P, Gallo M, Gauss G, Gerstein R, Islas A. The mechanism of V(D)J recombination: Site-specificity, reaction fidelity and immunologic diversity. Seminars in Immunology. 1994;6(3):143-153.
Lieber, Michael R. ; Chang, Ching-Pin ; Gallo, Michael ; Gauss, George ; Gerstein, Rachel ; Islas, Angel. / The mechanism of V(D)J recombination : Site-specificity, reaction fidelity and immunologic diversity. In: Seminars in Immunology. 1994 ; Vol. 6, No. 3. pp. 143-153.
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