The mechanism of v(d)j recombination: Site-specificity, reaction fidelity and immunologic diversity

Michael R. Lieber, Ching Pin Chang, Michael Gallo, George Gauss, Rachel Gerstein, Angel Islas

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Site-specific recombination reactions in higher eukaryotes are uncommon, perhaps because of the potential genomic instability that they may create. We focus this review on the issues of site-specificity, reaction fidelity and immunologic diversity in the V(D)J recombination reaction.

Original languageEnglish (US)
Pages (from-to)143-153
Number of pages11
JournalSeminars in Immunology
Volume6
Issue number3
DOIs
StatePublished - Jun 1994

Keywords

  • Accessibility
  • Antigen receptor genes
  • Gene rearrangement
  • Genome stability
  • Recombination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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