The method for breast cancer grade prediction and pathway analysis based on improved multiple kernel learning

Tianci Song, Yan Wang, Wei Du, Sha Cao, Yuan Tian, Yanchun Liang

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Breast cancer histologic grade represents the morphological assessment of the tumor's malignancy and aggressiveness, which is vital in clinically planning treatment and estimating prognosis for patients. Therefore, the prediction of breast cancer grade can markedly elevate the detection of early breast cancer and efficiently guide its treatment. With the advent of high-throughput profiling technology, a large number of data of different types are rapidly generated, and each data provides its unique biological insight. Although many researches focused on cancer grade prediction, hardly most of them attempted to integrate multiple data types, by which we cannot only improve and boost results obtained from learning method, but also have a good understanding or explanation of biological issues. In this paper, we take advantage of a sophisticated supervised learning method called multiple kernel learning (MKL) to design a breast cancer grading predictor fusing heterogeneous data for classification of breast cancer histopathology. Furthermore, we modify our model by involving biological pathway information. The new model can evaluate the significance of various pathways in which differential expression genes fall between different breast cancer grades. The merits of the novel model are lucubration in bridging between omics data and various phenotypes of breast cancer grades, and providing an auxiliary method integrating omics data of cancer mechanism research. In experiments, the proposed method outperforms other state-of-the-art methods and has abundant biological interpretation in explaining differences between breast cancer grades.

Original languageEnglish (US)
Article number1650037
JournalJournal of bioinformatics and computational biology
Volume15
Issue number1
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

Keywords

  • biological interpretation
  • breast cancer grade
  • feature selection
  • Multiple kernel learning (MKL)
  • omics data integration

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computer Science Applications

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