The microenvironment matters: Estrogen deficiency fuels cancer bone metastases

Laura E. Wright, Theresa A. Guise

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting.

Original languageEnglish (US)
Pages (from-to)2817-2819
Number of pages3
JournalClinical Cancer Research
Volume20
Issue number11
DOIs
StatePublished - Jun 1 2014

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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