The microenvironment matters: Estrogen deficiency fuels cancer bone metastases

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting.

Original languageEnglish
Pages (from-to)2817-2819
Number of pages3
JournalClinical Cancer Research
Volume20
Issue number11
DOIs
StatePublished - Jun 1 2014

Fingerprint

Bone Neoplasms
zoledronic acid
Bone Development
Estrogens
Bone Density Conservation Agents
Breast Neoplasms
Neoplasm Metastasis
Postmenopausal Osteoporosis
Bone Resorption
Phenotype
Bone and Bones
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

The microenvironment matters : Estrogen deficiency fuels cancer bone metastases. / Wright, Laura; Guise, Theresa.

In: Clinical Cancer Research, Vol. 20, No. 11, 01.06.2014, p. 2817-2819.

Research output: Contribution to journalArticle

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