The microenvironment reprograms circuits in tumor cells

Qingchun Cai, Yan Xu

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In the course of multistep oncogenesis, initially normal cells acquire several new functions that render them malignant. We have recently demonstrated that the peritoneal microenvironment promotes resistance to anoikis in ovarian cancer cells by reprogramming SRC/AKT/ERK signaling and metabolism. These findings have prognostic and therapeutic implications.

Original languageEnglish (US)
Article numbere969634
JournalMolecular and Cellular Oncology
Volume2
Issue number1
DOIs
StatePublished - Jan 2 2015

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Keywords

  • anoikis resistance
  • cell survival
  • floating cells
  • glycolysis
  • microenvironment
  • ovarian cancer
  • SRC

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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