The molecular characterization and therapeutic strategies of papillary renal cell carcinoma

Qiwei Chen, Liang Cheng, Quanlin Li

Research output: Contribution to journalReview article

Abstract

Introduction: Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behavior. In this review, we summarize the current progression on pRCC in molecular level. Our findings highlight the need for molecular markers to accurately subtype pRCC and may lead to the development of more targeted agents and better patient stratification in clinical trials for pRCC. Areas covered: This review highlights the need for molecular markers to accurately subtype PRCC and may lead to the development of more targeted agents and better patient stratification in clinical trials for pRCC. Expert commentary: There are mainly two subtypes of pRCC based on histology. However, little is known about the genetic characterization of the sporadic forms of pRCC and there are currently no standard forms of therapy for patients with advanced disease. Both MET inhibitors and immunotherapy may be effective in advanced pRCC treatment. Therefore, understanding the molecular basis of pRCC and identifying the main goal of treatment is crucial for the selection of the best strategy.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalExpert Review of Anticancer Therapy
Volume19
Issue number2
DOIs
StatePublished - Feb 1 2019

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Keywords

  • genetic
  • mutation
  • Papillary renal cell carcinoma
  • survival prognosis
  • the cancer genome atlas

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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