The molecular structure of indium oxine

M. A. Green, J. C. Huffman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The radiopharmaceutical use of [111In]oxine for radiolabeling of blood products has recently met with FDA approval. The molecular structure of tris(8-quinolinolato) indium(III), 'indium oxine', was determined by x-ray crystallography using a single yellow crystal grown from ethanol solution. The structural study reveals an asymmetric pseudo-octahedral N3O3 metal coordination sphere with meridional stereochemistry. This asymmetry is not detected in solution by proton NMR spectroscopy at room temperature; however, at -90°C spectroscopic changes suggest slowing of a fluxional process. The molecule unexpectedly crystallized with a molecule of ethanol hydrogen-bonded to an oxygen atom of one of the oxine ligands, suggesting that hydrogen-bonding will play a role in the solvation of this complex in protic solvents.

Original languageEnglish (US)
Pages (from-to)417-420
Number of pages4
JournalJournal of Nuclear Medicine
Issue number3
StatePublished - 1988

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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