The radiopharmaceutical use of [111In]oxine for radiolabeling of blood products has recently met with FDA approval. The molecular structure of tris(8-quinolinolato) indium(III), 'indium oxine', was determined by x-ray crystallography using a single yellow crystal grown from ethanol solution. The structural study reveals an asymmetric pseudo-octahedral N3O3 metal coordination sphere with meridional stereochemistry. This asymmetry is not detected in solution by proton NMR spectroscopy at room temperature; however, at -90°C spectroscopic changes suggest slowing of a fluxional process. The molecule unexpectedly crystallized with a molecule of ethanol hydrogen-bonded to an oxygen atom of one of the oxine ligands, suggesting that hydrogen-bonding will play a role in the solvation of this complex in protic solvents.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Nuclear Medicine|
|State||Published - 1988|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging