The molecular structure of indium oxine

Mark Green, J. C. Huffman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The radiopharmaceutical use of [111In]oxine for radiolabeling of blood products has recently met with FDA approval. The molecular structure of tris(8-quinolinolato) indium(III), 'indium oxine', was determined by x-ray crystallography using a single yellow crystal grown from ethanol solution. The structural study reveals an asymmetric pseudo-octahedral N3O3 metal coordination sphere with meridional stereochemistry. This asymmetry is not detected in solution by proton NMR spectroscopy at room temperature; however, at -90°C spectroscopic changes suggest slowing of a fluxional process. The molecule unexpectedly crystallized with a molecule of ethanol hydrogen-bonded to an oxygen atom of one of the oxine ligands, suggesting that hydrogen-bonding will play a role in the solvation of this complex in protic solvents.

Original languageEnglish (US)
Pages (from-to)417-420
Number of pages4
JournalJournal of Nuclear Medicine
Volume29
Issue number3
StatePublished - 1988
Externally publishedYes

Fingerprint

Molecular Structure
Ethanol
Oxyquinoline
Crystallography
Indium
Radiopharmaceuticals
Hydrogen Bonding
Protons
Hydrogen
Magnetic Resonance Spectroscopy
Metals
X-Rays
Oxygen
Ligands
Temperature
indium oxine

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

The molecular structure of indium oxine. / Green, Mark; Huffman, J. C.

In: Journal of Nuclear Medicine, Vol. 29, No. 3, 1988, p. 417-420.

Research output: Contribution to journalArticle

Green, M & Huffman, JC 1988, 'The molecular structure of indium oxine', Journal of Nuclear Medicine, vol. 29, no. 3, pp. 417-420.
Green, Mark ; Huffman, J. C. / The molecular structure of indium oxine. In: Journal of Nuclear Medicine. 1988 ; Vol. 29, No. 3. pp. 417-420.
@article{552fe167d3374c41b221fc2b34650852,
title = "The molecular structure of indium oxine",
abstract = "The radiopharmaceutical use of [111In]oxine for radiolabeling of blood products has recently met with FDA approval. The molecular structure of tris(8-quinolinolato) indium(III), 'indium oxine', was determined by x-ray crystallography using a single yellow crystal grown from ethanol solution. The structural study reveals an asymmetric pseudo-octahedral N3O3 metal coordination sphere with meridional stereochemistry. This asymmetry is not detected in solution by proton NMR spectroscopy at room temperature; however, at -90°C spectroscopic changes suggest slowing of a fluxional process. The molecule unexpectedly crystallized with a molecule of ethanol hydrogen-bonded to an oxygen atom of one of the oxine ligands, suggesting that hydrogen-bonding will play a role in the solvation of this complex in protic solvents.",
author = "Mark Green and Huffman, {J. C.}",
year = "1988",
language = "English (US)",
volume = "29",
pages = "417--420",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "3",

}

TY - JOUR

T1 - The molecular structure of indium oxine

AU - Green, Mark

AU - Huffman, J. C.

PY - 1988

Y1 - 1988

N2 - The radiopharmaceutical use of [111In]oxine for radiolabeling of blood products has recently met with FDA approval. The molecular structure of tris(8-quinolinolato) indium(III), 'indium oxine', was determined by x-ray crystallography using a single yellow crystal grown from ethanol solution. The structural study reveals an asymmetric pseudo-octahedral N3O3 metal coordination sphere with meridional stereochemistry. This asymmetry is not detected in solution by proton NMR spectroscopy at room temperature; however, at -90°C spectroscopic changes suggest slowing of a fluxional process. The molecule unexpectedly crystallized with a molecule of ethanol hydrogen-bonded to an oxygen atom of one of the oxine ligands, suggesting that hydrogen-bonding will play a role in the solvation of this complex in protic solvents.

AB - The radiopharmaceutical use of [111In]oxine for radiolabeling of blood products has recently met with FDA approval. The molecular structure of tris(8-quinolinolato) indium(III), 'indium oxine', was determined by x-ray crystallography using a single yellow crystal grown from ethanol solution. The structural study reveals an asymmetric pseudo-octahedral N3O3 metal coordination sphere with meridional stereochemistry. This asymmetry is not detected in solution by proton NMR spectroscopy at room temperature; however, at -90°C spectroscopic changes suggest slowing of a fluxional process. The molecule unexpectedly crystallized with a molecule of ethanol hydrogen-bonded to an oxygen atom of one of the oxine ligands, suggesting that hydrogen-bonding will play a role in the solvation of this complex in protic solvents.

UR - http://www.scopus.com/inward/record.url?scp=0023852166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023852166&partnerID=8YFLogxK

M3 - Article

VL - 29

SP - 417

EP - 420

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 3

ER -