The morbidity of C. difficile in necrotizing pancreatitis

Thomas K. Maatman, Jamaica A. Westfall-Snyder, Megan E. Nicolas, Elliott J. Yee, Eugene P. Ceppa, Michael House, Attila Nakeeb, C. Max Schmidt, Nicholas Zyromski

Research output: Contribution to journalArticle

Abstract

Introduction: Necrotizing pancreatitis (NP) patients commonly require antibiotic treatment during the several month-long disease course. We hypothesized that Clostridium difficile infection (CDI) is common in NP and significantly impacts outcomes. Materials and methods: Retrospective review of 704 NP patients treated at a single-institution (2005–2018). Results: 10% (67/704) of patients developed CDI a mean 78 days after NP onset. Patients developing CDI experienced increased total hospital days (CDI, 104; No CDI, 42; P < 0.001), readmission rates (CDI, 85%; No CDI, 64%; P = 0.006), and duration of NP (CDI, 248 days; No CDI, 183; P = 0.001). Risk factors for CDI included antibiotic use (OR, 96.2; 95% CI, 5.9–1556.2; P = 0.001) and any organ failure (OR, 2.0; 95% CI, 1.2–3.3, P = 0.008). Mortality was not affected by CDI (CDI, 10%; No CDI, 9%; P = 0.7). Conclusion: Clostridium difficile infection is common in necrotizing pancreatitis and negatively impacts morbidity and disease recovery.

Original languageEnglish (US)
JournalAmerican Journal of Surgery
DOIs
StateAccepted/In press - Jan 1 2019

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Clostridium Infections
Clostridium difficile
Pancreatitis
Morbidity
Anti-Bacterial Agents

Keywords

  • Antibiotics
  • Clostridium difficile infection
  • Colitis
  • Infectious diarrhea
  • Necrotizing pancreatitis

ASJC Scopus subject areas

  • Surgery

Cite this

Maatman, T. K., Westfall-Snyder, J. A., Nicolas, M. E., Yee, E. J., Ceppa, E. P., House, M., ... Zyromski, N. (Accepted/In press). The morbidity of C. difficile in necrotizing pancreatitis. American Journal of Surgery. https://doi.org/10.1016/j.amjsurg.2019.08.006

The morbidity of C. difficile in necrotizing pancreatitis. / Maatman, Thomas K.; Westfall-Snyder, Jamaica A.; Nicolas, Megan E.; Yee, Elliott J.; Ceppa, Eugene P.; House, Michael; Nakeeb, Attila; Schmidt, C. Max; Zyromski, Nicholas.

In: American Journal of Surgery, 01.01.2019.

Research output: Contribution to journalArticle

Maatman, Thomas K. ; Westfall-Snyder, Jamaica A. ; Nicolas, Megan E. ; Yee, Elliott J. ; Ceppa, Eugene P. ; House, Michael ; Nakeeb, Attila ; Schmidt, C. Max ; Zyromski, Nicholas. / The morbidity of C. difficile in necrotizing pancreatitis. In: American Journal of Surgery. 2019.
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