The morphologic effects of simultaneous infusion of levarterenol and phentolamine on the canine myocardium

E. L. Bove, L. C. Argenta, V. M. Cimmino, J. W. Brown, R. H. Nishiyama, M. M. Kirsh

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The effect of simultaneous administration of levarterenol and phentolamine on the myocardium over a 3 hr period was studied in 15 adult mongrel dogs. All animals receiving levarterenol alone had moderate to severe subendocardial hemorrhage and necrosis. Four of the 6 animals receiving the simultaneous infusion of levarterenol and phentolamine had little or no hemorrhage or necrosis. These differences are significant (p < 0.02). It is concluded that the administration of phentolamine simultaneously with levarterenol affords a significant protective effect on the myocardium.

Original languageEnglish (US)
Pages (from-to)701-706
Number of pages6
JournalUnknown Journal
Volume70
Issue number4
DOIs
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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