The morphologic effects of simultaneous infusion of levarterenol and phentolamine on the canine myocardium

E. L. Bove, L. C. Argenta, V. M. Cimmino, John Brown, R. H. Nishiyama, M. M. Kirsh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of simultaneous administration of levarterenol and phentolamine on the myocardium over a 3 hr period was studied in 15 adult mongrel dogs. All animals receiving levarterenol alone had moderate to severe subendocardial hemorrhage and necrosis. Four of the 6 animals receiving the simultaneous infusion of levarterenol and phentolamine had little or no hemorrhage or necrosis. These differences are significant (p <0.02). It is concluded that the administration of phentolamine simultaneously with levarterenol affords a significant protective effect on the myocardium.

Original languageEnglish (US)
Pages (from-to)701-706
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume70
Issue number4
StatePublished - 1975
Externally publishedYes

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Phentolamine
Canidae
Myocardium
Norepinephrine
Necrosis
Hemorrhage
Dogs

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

The morphologic effects of simultaneous infusion of levarterenol and phentolamine on the canine myocardium. / Bove, E. L.; Argenta, L. C.; Cimmino, V. M.; Brown, John; Nishiyama, R. H.; Kirsh, M. M.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 70, No. 4, 1975, p. 701-706.

Research output: Contribution to journalArticle

Bove, E. L. ; Argenta, L. C. ; Cimmino, V. M. ; Brown, John ; Nishiyama, R. H. ; Kirsh, M. M. / The morphologic effects of simultaneous infusion of levarterenol and phentolamine on the canine myocardium. In: Journal of Thoracic and Cardiovascular Surgery. 1975 ; Vol. 70, No. 4. pp. 701-706.
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