The mouse as a model system to study cardiac regeneration

Marc Michael Zaruba, Loren Field

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cardiomyocytes exhibit robust proliferative activity during development. After birth, cardiomyocyte proliferation is markedly reduced. Consequently, regenerative growth in the postnatal heart via cardiomyocyte proliferation (including, by inference, via the proliferation of stem cell derived cardiomyocytes) is limited and often insufficient to effect repair following injury. Here we review methodologies which employ the mouse as a model system to study cardiac regeneration, and in particular cardiomyocyte replenishment, in health and disease.

Original languageEnglish
Pages (from-to)165-171
Number of pages7
JournalDrug Discovery Today: Disease Models
Volume5
Issue number3
DOIs
StatePublished - Sep 2008

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Cardiac Myocytes
Regeneration
Stem Cells
Parturition
Health
Wounds and Injuries
Growth

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

The mouse as a model system to study cardiac regeneration. / Zaruba, Marc Michael; Field, Loren.

In: Drug Discovery Today: Disease Models, Vol. 5, No. 3, 09.2008, p. 165-171.

Research output: Contribution to journalArticle

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