The mouse as a model system to study cardiac regeneration

Marc Michael Zaruba, Loren J. Field

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Cardiomyocytes exhibit robust proliferative activity during development. After birth, cardiomyocyte proliferation is markedly reduced. Consequently, regenerative growth in the postnatal heart via cardiomyocyte proliferation (including, by inference, via the proliferation of stem cell derived cardiomyocytes) is limited and often insufficient to effect repair following injury. Here we review methodologies which employ the mouse as a model system to study cardiac regeneration, and in particular cardiomyocyte replenishment, in health and disease.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalDrug Discovery Today: Disease Models
Issue number3
StatePublished - Sep 1 2008

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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