The moving target induced dosimetric effect vs. beam direction in proton radiotherapy of moving lung tumors

Li Zhao, George Sandison, Jonathan Farr, Huanmei Wu, Markus Fitzek

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The treatment of moving targets is a primary challenge of radiotherapy. Internal margin has been widely used to account for the geometric displacement of moving targets. However, it has not been fully addressed if internal margin is beam specific, rather than purely geometric. A tissue equivalent thorax phantom with a tumor placed in the right lung is used in our study. The simulated tumor moves in three directions, superior-inferior (SI), anterior-posterior (AP), right-left (RL) with 6 and 12 mm displacements. The dose distribution was recalculated for each position simulated. The resultant dose distribution is analyzed to provide insights of internal margin setup. Our results show that the internal motion induced dose error is considerably less along the beam axis than it is laterally. Therefore, the beam direction needs to be considered when the internal margin is used to account for the tumor motion in the treatment of lung cancer with proton therapy.

Original languageEnglish (US)
Title of host publicationBioMedical Engineering and Informatics
Subtitle of host publicationNew Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
Pages804-808
Number of pages5
DOIs
StatePublished - Sep 18 2008
EventBioMedical Engineering and Informatics: New Development and the Future - 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 - Sanya, Hainan, China
Duration: May 27 2008May 30 2008

Publication series

NameBioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
Volume2

Other

OtherBioMedical Engineering and Informatics: New Development and the Future - 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
CountryChina
CitySanya, Hainan
Period5/27/085/30/08

ASJC Scopus subject areas

  • Information Systems
  • Signal Processing
  • Biomedical Engineering

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  • Cite this

    Zhao, L., Sandison, G., Farr, J., Wu, H., & Fitzek, M. (2008). The moving target induced dosimetric effect vs. beam direction in proton radiotherapy of moving lung tumors. In BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008 (pp. 804-808). [4549287] (BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008; Vol. 2). https://doi.org/10.1109/BMEI.2008.317