The natural history of intimal flaps in a canine model

Alan Sawchuk, J. Eldrup-Jorgensen, C. Tober, D. McCoy, J. Durham, B. Waller, J. J. Schuler, P. Flanigan

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The natural history of arterial intimal flaps has not been well defined. This study characterizes the natural history of unrepaired intimal flaps. Thirty-nine 1-, 2-, and 3-mm hemispheric, distally based intimal flaps were made in 4- to 5-mm diameter canine femoral and carotid arteries. Twenty arteries had 2- and 3-mm intimal flaps and were monitored for short-term arterial thrombosis and flap extension. Nineteen had 1- and 2-mm intimal flaps and were monitored for thrombosis, long-term development of neointimal hyperplasia, arterial stenosis, and persistence of the flap. While 40% of the arteries with 3-mm intimal flaps developed thrombosis in 3 to 5 days, only 3% of the arteries with 1- or 2-mm intimal flaps developed thrombosis. Most 1- or 2-mm intimal flaps resolved and the subsequent development of neointimal hyperplasia or arterial stenosis was minimal. Arteries with hemodynamically significant stenoses from intimal flaps warrant repair, while arteries with smaller intimal flaps may not require repair.

Original languageEnglish
Pages (from-to)1614-1616
Number of pages3
JournalArchives of Surgery
Volume125
Issue number12
StatePublished - 1990

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Tunica Intima
Natural History
Canidae
Arteries
Thrombosis
Pathologic Constriction
Hyperplasia
Femoral Artery
Carotid Arteries

ASJC Scopus subject areas

  • Surgery

Cite this

Sawchuk, A., Eldrup-Jorgensen, J., Tober, C., McCoy, D., Durham, J., Waller, B., ... Flanigan, P. (1990). The natural history of intimal flaps in a canine model. Archives of Surgery, 125(12), 1614-1616.

The natural history of intimal flaps in a canine model. / Sawchuk, Alan; Eldrup-Jorgensen, J.; Tober, C.; McCoy, D.; Durham, J.; Waller, B.; Schuler, J. J.; Flanigan, P.

In: Archives of Surgery, Vol. 125, No. 12, 1990, p. 1614-1616.

Research output: Contribution to journalArticle

Sawchuk, A, Eldrup-Jorgensen, J, Tober, C, McCoy, D, Durham, J, Waller, B, Schuler, JJ & Flanigan, P 1990, 'The natural history of intimal flaps in a canine model', Archives of Surgery, vol. 125, no. 12, pp. 1614-1616.
Sawchuk A, Eldrup-Jorgensen J, Tober C, McCoy D, Durham J, Waller B et al. The natural history of intimal flaps in a canine model. Archives of Surgery. 1990;125(12):1614-1616.
Sawchuk, Alan ; Eldrup-Jorgensen, J. ; Tober, C. ; McCoy, D. ; Durham, J. ; Waller, B. ; Schuler, J. J. ; Flanigan, P. / The natural history of intimal flaps in a canine model. In: Archives of Surgery. 1990 ; Vol. 125, No. 12. pp. 1614-1616.
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