The need for translational research on drug-drug interactions

S. Hennessy, D. A. Flockhart

Research output: Contribution to journalComment/debate

20 Scopus citations

Abstract

Drug-drug interactions (DDIs) are an important clinical and public health concern. Although DDI screening now occurs during drug development, it is difficult to predict clinical importance based on in vitro experiments. Furthermore, older drugs that were not screened may have interactions that have not yet been identified. In this Commentary, we review the importance of DDIs and argue that a translational research approach is needed to produce clinically actionable information as well as generalizable biological knowledge.

Original languageEnglish (US)
Pages (from-to)771-773
Number of pages3
JournalClinical Pharmacology and Therapeutics
Volume91
Issue number5
DOIs
StatePublished - May 2012

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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